<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/nport" xmlns:com="http://www.sec.gov/edgar/common" xmlns:ncom="http://www.sec.gov/edgar/nportcommon" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.sec.gov/edgar/nport eis_NPORT_Filer.xsd">
  <headerData>
    <submissionType>NPORT-P</submissionType>
    <isConfidential>false</isConfidential>
    <filerInfo>

      <filer>
        <issuerCredentials>
          <cik>0000745463</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>


      <seriesClassInfo>
        <seriesId>S000005289</seriesId>
        <classId>C000014454</classId>
        <classId>C000243418</classId>
        <classId>C000081635</classId>
        <classId>C000014456</classId>
      </seriesClassInfo>


    </filerInfo>
  </headerData>
  <formData>
    <genInfo>
      <regName>EATON VANCE MUTUAL FUNDS TRUST</regName>
      <regFileNumber>811-04015</regFileNumber>
      <regCik>0000745463</regCik>
      <regLei>549300C67AFHZKODE756</regLei>
      <regStreet1>One Post Office Square</regStreet1>
      <regCity>Boston</regCity>
      <regStateConditional regCountry="US" regState="US-MA"/>
      <regZipOrPostalCode>02109</regZipOrPostalCode>
      <regPhone>617-482-8260</regPhone>
      <seriesName>Eaton Vance High Income Opportunities Fund</seriesName>
      <seriesId>S000005289</seriesId>
      <seriesLei>5493007LKVVTYHUQ1Q66</seriesLei>
      <repPdEnd>2024-10-31</repPdEnd>
      <repPdDate>2024-04-30</repPdDate>
      <isFinalFiling>N</isFinalFiling>
    </genInfo>
    <fundInfo>
      <totAssets>992110691.99</totAssets>
      <totLiabs>5887056.00</totLiabs>
      <netAssets>986223635.99</netAssets>
      <assetsAttrMiscSec>0.00000000</assetsAttrMiscSec>
      <assetsInvested>0.00000000</assetsInvested>
      <amtPayOneYrBanksBorr>0.00000000</amtPayOneYrBanksBorr>
      <amtPayOneYrCtrldComp>0.00000000</amtPayOneYrCtrldComp>
      <amtPayOneYrOthAffil>0.00000000</amtPayOneYrOthAffil>
      <amtPayOneYrOther>0.00000000</amtPayOneYrOther>
      <amtPayAftOneYrBanksBorr>0.00000000</amtPayAftOneYrBanksBorr>
      <amtPayAftOneYrCtrldComp>0.00000000</amtPayAftOneYrCtrldComp>
      <amtPayAftOneYrOthAffil>0.00000000</amtPayAftOneYrOthAffil>
      <amtPayAftOneYrOther>0.00000000</amtPayAftOneYrOther>
      <delayDeliv>0.00000000</delayDeliv>
      <standByCommit>0.00000000</standByCommit>
      <liquidPref>0.00000000</liquidPref>
      <cshNotRptdInCorD>0.00000000</cshNotRptdInCorD>
      <isNonCashCollateral>N</isNonCashCollateral>
      <returnInfo>
        <monthlyTotReturns>
          <monthlyTotReturn classId="C000014454" rtn1="0.26000000" rtn2="1.25000000" rtn3="-0.69000000"/>
          <monthlyTotReturn classId="C000243418" rtn1="0.29000000" rtn2="1.28000000" rtn3="-0.65000000"/>
          <monthlyTotReturn classId="C000081635" rtn1="0.04000000" rtn2="1.51000000" rtn3="-0.90000000"/>
          <monthlyTotReturn classId="C000014456" rtn1="-0.04000000" rtn2="1.43000000" rtn3="-0.98000000"/>
        </monthlyTotReturns>
        <othMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
        <othMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
        <othMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
      </returnInfo>
      <mon1Flow redemption="22171414.93000000" reinvestment="4212452.41000000" sales="41663697.51000000"/>
      <mon2Flow redemption="20696488.23000000" reinvestment="4359512.57000000" sales="26526194.77000000"/>
      <mon3Flow redemption="31691313.63000000" reinvestment="4649595.98000000" sales="86552892.22000000"/>

      <varInfo>

        <fundsDesignatedInfo>
          <nameDesignatedIndex>BofAML High Yield-USD</nameDesignatedIndex>
          <indexIdentifier>ML_HY</indexIdentifier>

        </fundsDesignatedInfo>

      </varInfo>
    </fundInfo>
    <invstOrSecs>
      <invstOrSec>
        <name>HIGH INCOME OPPORTUNITIES PORTFOLIO</name>
        <lei>Q9J0C6S550YJ63X9DD38</lei>
        <title>HIGH INCOME OPPORTUNITIES PORTFOLIO</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="FR8A_MASTER"/>
        </identifiers>
        <balance>123359763.88000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>991812501.56000000</valUSD>
        <pctVal>100.5666935333</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>N/A</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>

    </explntrNotes>
    <signature>
      <ncom:dateSigned>2024-05-21</ncom:dateSigned>
      <ncom:nameOfApplicant>EATON VANCE MUTUAL FUNDS TRUST</ncom:nameOfApplicant>
      <ncom:signature>James Kirchner</ncom:signature>
      <ncom:signerName>James Kirchner</ncom:signerName>
      <ncom:title>Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
