Stockholders' Equity (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2025	Mar. 31, 2024
Increase (Decrease) in Stockholders' Equity
Balance, beginning	$ 747,005	$ 429,171
Balance, beginning (in shares)	66,374,549
Shares issued under stock option and employee stock purchase plans	$ 202	3,814
Shares issued in underwritten offering, net		432,298
Stock-based compensation	9,316	7,202
Unrealized gain (loss) on marketable securities	254	(1,064)
Net loss	(53,796)	(32,808)
Balance, ending	$ 702,981	838,613
Balance, ending (in shares)	66,384,191
Common Stock
Increase (Decrease) in Stockholders' Equity
Balance, beginning	$ 66	$ 56
Balance, beginning (in shares)	66,374,549	55,883,377
Shares issued under stock option and employee stock purchase plans (in shares)	9,642	229,171
Shares issued in underwritten offering, net		$ 10
Shares issued in underwritten offering, net (in shares)		9,798,000
Balance, ending	$ 66	$ 66
Balance, ending (in shares)	66,384,191	65,910,548
Additional Paid-In Capital
Increase (Decrease) in Stockholders' Equity
Balance, beginning	$ 2,298,849	$ 1,823,168
Shares issued under stock option and employee stock purchase plans	202	3,814
Shares issued in underwritten offering, net		432,288
Stock-based compensation	9,316	7,202
Balance, ending	2,308,367	2,266,472
Accumulated Other Comprehensive Income
Increase (Decrease) in Stockholders' Equity
Balance, beginning	3,314	3,308
Unrealized gain (loss) on marketable securities	254	(1,064)
Balance, ending	3,568	2,244
Accumulated Deficit
Increase (Decrease) in Stockholders' Equity
Balance, beginning	(1,555,224)	(1,397,361)
Net loss	(53,796)	(32,808)
Balance, ending	$ (1,609,020)	$ (1,430,169)