Income Taxes - Reconciliation (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Reconciliation between the amount of reported income tax and the amount computed using U.S. Statutory rate
Pre-tax loss	$ (157,863)	$ (141,429)	$ (112,325)
Loss at statutory rates	(33,151)	(29,700)	(23,588)
Research and development credits	(7,332)	(5,237)	(3,876)
State taxes	(15,375)	(13,691)	(9,606)
Other	662	(1,130)	11,421
Change in fair value remeasurement of contingent consideration			(1,441)
Expiration of Federal and State NOLs and R&D credits	82,825	15,141	16,862
Change in valuation allowance	$ (27,629)	$ 34,617	$ 10,228