Stockholders' Equity (Details) - USD ($) $ in Thousands	3 Months Ended						9 Months Ended
	Sep. 30, 2024	Jun. 30, 2024	Mar. 31, 2024	Sep. 30, 2023	Jun. 30, 2023	Mar. 31, 2023	Sep. 30, 2024	Sep. 30, 2023
Increase (Decrease) in Stockholders' Equity
Balance, beginning	$ 813,659	$ 838,613	$ 429,171	$ 277,537	$ 302,740	$ 326,204	$ 429,171	$ 326,204
Balance, beginning (in shares)			55,883,377				55,883,377
Shares issued under stock option and employee stock purchase plans	1,239	3,712	$ 3,814	257	133	694
Shares issued in underwritten offering, net			432,298
Stock-based compensation	9,620	7,640	7,202	7,121	5,217	4,340
Unrealized gain on marketable securities	3,508	(464)	(1,064)	63	(51)	863	$ 1,980	875
Net loss	(42,121)	(35,842)	(32,808)	(38,260)	(30,502)	(29,361)	(110,771)	(98,123)
Balance, ending	$ 785,905	813,659	838,613	246,718	277,537	302,740	$ 785,905	246,718
Balance, ending (in shares)	66,344,236						66,344,236
Common Stock
Increase (Decrease) in Stockholders' Equity
Balance, beginning	$ 66	$ 66	$ 56	$ 47	$ 47	$ 47	$ 56	$ 47
Balance, beginning (in shares)	66,280,667	65,910,548	55,883,377	47,253,813	47,244,681	47,200,695	55,883,377	47,200,695
Shares issued under stock option and employee stock purchase plans (in shares)	63,569	370,119	229,171	10,384	9,132	43,986
Shares issued in underwritten offering, net			$ 10
Shares issued in underwritten offering, net (in shares)			9,798,000
Balance, ending	$ 66	$ 66	$ 66	$ 47	$ 47	$ 47	$ 66	$ 47
Balance, ending (in shares)	66,344,236	66,280,667	65,910,548	47,264,197	47,253,813	47,244,681	66,344,236	47,264,197
Additional Paid-In Capital
Increase (Decrease) in Stockholders' Equity
Balance, beginning	$ 2,277,824	$ 2,266,472	$ 1,823,168	$ 1,591,213	$ 1,585,863	$ 1,580,829	$ 1,823,168	$ 1,580,829
Shares issued under stock option and employee stock purchase plans	1,239	3,712	3,814	257	133	694
Shares issued in underwritten offering, net			432,288
Stock-based compensation	9,620	7,640	7,202	7,121	5,217	4,340
Balance, ending	2,288,683	2,277,824	2,266,472	1,598,591	1,591,213	1,585,863	2,288,683	1,598,591
Accumulated Other Comprehensive Income
Increase (Decrease) in Stockholders' Equity
Balance, beginning	1,780	2,244	3,308	2,072	2,123	1,260	3,308	1,260
Unrealized gain on marketable securities	3,508	(464)	(1,064)	63	(51)	863
Balance, ending	5,288	1,780	2,244	2,135	2,072	2,123	5,288	2,135
Accumulated Deficit
Increase (Decrease) in Stockholders' Equity
Balance, beginning	(1,466,011)	(1,430,169)	(1,397,361)	(1,315,795)	(1,285,293)	(1,255,932)	(1,397,361)	(1,255,932)
Net loss	(42,121)	(35,842)	(32,808)	(38,260)	(30,502)	(29,361)
Balance, ending	$ (1,508,132)	$ (1,466,011)	$ (1,430,169)	$ (1,354,055)	$ (1,315,795)	$ (1,285,293)	$ (1,508,132)	$ (1,354,055)