Stockholders' Equity (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2026	Mar. 31, 2025
Increase (Decrease) in Stockholders' Equity
Balance, beginning	$ 527,165	$ 747,005
Balance, beginning (in shares)	66,549,442
Shares issued under stock option and employee stock purchase plans	$ 327	202
Stock-based compensation	8,523	9,316
Unrealized (loss) gain on marketable securities	(1,104)	254
Net Income (Loss)	(78,685)	(53,796)
Balance, ending	$ 456,226	702,981
Balance, ending (in shares)	66,568,971
Common Stock
Increase (Decrease) in Stockholders' Equity
Balance, beginning	$ 67	$ 66
Balance, beginning (in shares)	66,549,442	66,374,549
Shares issued under stock option and employee stock purchase plans (in shares)	19,529	9,642
Balance, ending	$ 67	$ 66
Balance, ending (in shares)	66,568,971	66,384,191
Additional Paid-In Capital
Increase (Decrease) in Stockholders' Equity
Balance, beginning	$ 2,337,453	$ 2,298,849
Shares issued under stock option and employee stock purchase plans	327	202
Stock-based compensation	8,523	9,316
Balance, ending	2,346,303	2,308,367
Accumulated Other Comprehensive Income
Increase (Decrease) in Stockholders' Equity
Balance, beginning	3,626	3,314
Unrealized (loss) gain on marketable securities	(1,104)	254
Balance, ending	2,522	3,568
Accumulated Deficit
Increase (Decrease) in Stockholders' Equity
Balance, beginning	(1,813,981)	(1,555,224)
Net Income (Loss)	(78,685)	(53,796)
Balance, ending	$ (1,892,666)	$ (1,609,020)