CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Income	Accumulated Deficit	Total
Balance, beginning at Dec. 31, 2022	$ 47	$ 1,580,829	$ 1,260	$ (1,255,932)	$ 326,204
Balance, beginning (in shares) at Dec. 31, 2022	47,200,695
Increase (Decrease) in Stockholders' Equity
Shares issued under stock option and employee stock purchase plans		2,236			2,236
Shares issued under stock option and employee stock purchase plans (in shares)	143,932
Shares issued in underwritten offering, net	$ 9	216,213			216,222
Shares issued in underwritten offering, net (in shares)	8,538,750
Stock-based compensation		23,890			23,890
Unrealized gain on marketable securities			2,048		2,048
Net loss				(141,429)	(141,429)
Balance, ending at Dec. 31, 2023	$ 56	1,823,168	3,308	(1,397,361)	429,171
Balance, ending (in shares) at Dec. 31, 2023	55,883,377
Increase (Decrease) in Stockholders' Equity
Shares issued under stock option and employee stock purchase plans		9,151			9,151
Shares issued under stock option and employee stock purchase plans (in shares)	693,172
Shares issued in underwritten offering, net	$ 10	432,288			432,298
Shares issued in underwritten offering, net (in shares)	9,798,000
Stock-based compensation		34,242			34,242
Unrealized gain on marketable securities			6		6
Net loss				(157,863)	(157,863)
Balance, ending at Dec. 31, 2024	$ 66	2,298,849	3,314	(1,555,224)	$ 747,005
Balance, ending (in shares) at Dec. 31, 2024	66,374,549				66,374,549
Increase (Decrease) in Stockholders' Equity
Shares issued under stock option and employee stock purchase plans	$ 1	2,387			$ 2,388
Shares issued under stock option and employee stock purchase plans (in shares)	174,893
Stock-based compensation		36,217			36,217
Unrealized gain on marketable securities			312		312
Net loss				(258,757)	(258,757)
Balance, ending at Dec. 31, 2025	$ 67	$ 2,337,453	$ 3,626	$ (1,813,981)	$ 527,165
Balance, ending (in shares) at Dec. 31, 2025	66,549,442				66,549,442