CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Revenues:
Total revenues	$ 1,545	$ 7,020	$ 6,883
Operating expenses:
Research and development	245,074	163,550	118,011
General and administrative	43,838	38,548	30,914
Litigation settlement related loss			12,500
Total operating expenses	288,912	202,098	161,425
Operating loss	(287,367)	(195,078)	(154,542)
Investment and other income, net	28,610	37,215	13,113
Net loss	$ (258,757)	$ (157,863)	$ (141,429)
Basic net loss per common share (in dollars per share)	$ (3.9)	$ (2.45)	$ (2.92)
Diluted net loss per common share (in dollars per share)	$ (3.9)	$ (2.45)	$ (2.92)
Shares used in calculating basic net loss per share (in shares)	66,422	64,395	48,449
Shares used in calculating diluted net loss per share (in shares)	66,422	64,395	48,449
Comprehensive loss:
Net loss	$ (258,757)	$ (157,863)	$ (141,429)
Other comprehensive income (loss):
Unrealized gain on marketable securities	312	6	2,048
Comprehensive loss	(258,445)	(157,857)	(139,381)
Product development and licensing agreements
Revenues:
Total revenues	97	13	278
Contracts and grants
Revenues:
Total revenues	$ 1,448	$ 7,007	$ 6,605