Property and Equipment, Net (Details) - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Property and Equipment
Total Property and Equipment	$ 32,434	$ 32,295
Less: Accumulated Depreciation and Amortization	(28,403)	(26,184)
Property and Equipment, Net	4,031	6,111
Depreciation and amortization expense	4,858	3,577	$ 4,414
Laboratory equipment
Property and Equipment
Total Property and Equipment	8,622	8,272
Manufacturing equipment
Property and Equipment
Total Property and Equipment	2,510	2,497
Office furniture and equipment
Property and Equipment
Total Property and Equipment	3,873	3,791
Leasehold Improvements
Property and Equipment
Total Property and Equipment	17,238	17,408
Construction in Progress
Property and Equipment
Total Property and Equipment	191	327
Property Plant and Equipment
Property and Equipment
Depreciation and amortization expense	$ 2,700	$ 3,600	$ 4,400

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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