X0202 4 2005-12-28 0000743884 MACROCHEM CORP MCMP.OB 0001225978 SCO CAPITAL PARTNERS LLC 1285 AVENUE OF THE AMERICAS 35TH FLOOR NEW YORK NY 10019 0 0 1 0 0001294343 Rouhandeh Steven H C/O SCO CAPITAL PARTNERS LLC 1285 AVENUE OF THE AMERICAS, 35TH FLOOR NEW YORK NY 10019 0 0 1 0 Placement Agent Warrants .175 2005-12-28 4 J 0 285714 D 2005-12-23 2011-12-23 Common Stock 285714 1142857 D Placement Agent Warrants .175 2005-12-28 4 J 0 142857 D 2005-12-23 2011-12-23 Common Stock 142857 1000000 D Placement Agent Warrants .175 2005-12-28 4 J 0 142857 D 2005-12-23 2011-12-23 Common Stock 142857 857143 D SCO Securities LLC received these Placement Agent Warrants as partial consideration for its services in connection with the private placement of securities effected by the issuer on December 23, 2005. The transactions described herein reflect the allocation and transfer of such Placement Agent Warrants to certain employees and affiliates of SCO Securities LLC. Amounts reflect adjustment for the 1 for 7 reverse stock split effected by the issuer on December 30, 2005. This Form 4 is being filed by Steven H. Rouhandeh individually and by SCO Capital Partners LLC, an entity of which Mr. Rouhandeh is the sole member. SCO Capital Partners LLC is the direct beneficial owner of these securities. SCO Capital Partners LLC 2006-01-03 Steven H. Rouhandeh 2006-01-03