<?xml version="1.0" encoding="UTF-8"?>
<twe:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:fee="http://www.sec.gov/edgar/feecommon" xmlns:sta="http://www.sec.gov/edgar/statecodes" xmlns:scc="http://www.sec.gov/edgar/sccommon" xmlns:twe="http://www.sec.gov/edgar/twentyfourf2filer">
  <twe:schemaVersion>X0101</twe:schemaVersion>
  <twe:headerData>
    <twe:submissionType>24F-2NT</twe:submissionType>
    <twe:filerInfo>
      <twe:liveTestFlag>LIVE</twe:liveTestFlag>
      <twe:filer>
        <twe:issuerCredentials>
          <twe:cik>742212</twe:cik>
          <twe:ccc>XXXXXXXX</twe:ccc>
        </twe:issuerCredentials>
      </twe:filer>
      <twe:flags>
        <twe:confirmingCopyFlag>false</twe:confirmingCopyFlag>
      </twe:flags>
      <twe:investmentCompanyType>N-1A</twe:investmentCompanyType>
    </twe:filerInfo>
  </twe:headerData>
  <twe:formData>
    <twe:annualFilings>
      <twe:annualFilingInfo>
        <twe:item1>
          <twe:nameOfIssuer>NORTHWESTERN MUTUAL SERIES FUND INC</twe:nameOfIssuer>
          <twe:addressOfIssuer>
            <twe:street1>720 East Wisconsin Avenue</twe:street1>
            <twe:city>Milwaukee</twe:city>
            <twe:state>WI</twe:state>
            <twe:country>X1</twe:country>
            <twe:zipCode>53202</twe:zipCode>
          </twe:addressOfIssuer>
        </twe:item1>
        <twe:item2>
          <twe:reportSeriesClass>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>SMALL CAP GROWTH STOCK PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000039</twe:seriesId>
              <twe:classInfo>
                <twe:className>Small Cap Growth Stock Portfolio</twe:className>
                <twe:classId>C000000074</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>LARGE CAP CORE STOCK PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000040</twe:seriesId>
              <twe:classInfo>
                <twe:className>Large Cap Core Stock Portfolio</twe:className>
                <twe:classId>C000000075</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>DOMESTIC EQUITY PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000041</twe:seriesId>
              <twe:classInfo>
                <twe:className>Domestic Equity Portfolio</twe:className>
                <twe:classId>C000000076</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>EQUITY INCOME PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000042</twe:seriesId>
              <twe:classInfo>
                <twe:className>Equity Income Portfolio</twe:className>
                <twe:classId>C000000077</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>INDEX 500 STOCK PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000043</twe:seriesId>
              <twe:classInfo>
                <twe:className>Index 500 Stock Portfolio</twe:className>
                <twe:classId>C000000078</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>ASSET ALLOCATION PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000044</twe:seriesId>
              <twe:classInfo>
                <twe:className>Asset Allocation Portfolio</twe:className>
                <twe:classId>C000000079</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>BALANCED PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000045</twe:seriesId>
              <twe:classInfo>
                <twe:className>Balanced Portfolio</twe:className>
                <twe:classId>C000000080</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>HIGH YIELD BOND PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000046</twe:seriesId>
              <twe:classInfo>
                <twe:className>High Yield Bond Portfolio</twe:className>
                <twe:classId>C000000081</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>SELECT BOND PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000047</twe:seriesId>
              <twe:classInfo>
                <twe:className>Select Bond Portfolio</twe:className>
                <twe:classId>C000000082</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>GOVERNMENT MONEY MARKET PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000048</twe:seriesId>
              <twe:classInfo>
                <twe:className>Government Money Market Portfolio</twe:className>
                <twe:classId>C000000083</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>SMALL CAP VALUE PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000049</twe:seriesId>
              <twe:classInfo>
                <twe:className>Small Cap Value Portfolio</twe:className>
                <twe:classId>C000000084</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>MID CAP GROWTH STOCK PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000050</twe:seriesId>
              <twe:classInfo>
                <twe:className>Mid Cap Growth Stock Portfolio</twe:className>
                <twe:classId>C000000085</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>INTERNATIONAL GROWTH PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000051</twe:seriesId>
              <twe:classInfo>
                <twe:className>International Growth Portfolio</twe:className>
                <twe:classId>C000000086</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>INTERNATIONAL EQUITY PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000052</twe:seriesId>
              <twe:classInfo>
                <twe:className>International Equity Portfolio</twe:className>
                <twe:classId>C000000087</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>MID CAP VALUE PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000053</twe:seriesId>
              <twe:classInfo>
                <twe:className>Mid Cap Value Portfolio</twe:className>
                <twe:classId>C000000088</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>INDEX 400 STOCK PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000054</twe:seriesId>
              <twe:classInfo>
                <twe:className>Index 400 Stock Portfolio</twe:className>
                <twe:classId>C000000089</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>FOCUSED APPRECIATION PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000055</twe:seriesId>
              <twe:classInfo>
                <twe:className>Focused Appreciation Portfolio</twe:className>
                <twe:classId>C000000090</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>GROWTH STOCK PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000000056</twe:seriesId>
              <twe:classInfo>
                <twe:className>Growth Stock Portfolio</twe:className>
                <twe:classId>C000000091</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>LARGE COMPANY VALUE PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000018227</twe:seriesId>
              <twe:classInfo>
                <twe:className>Large Company Value Portfolio</twe:className>
                <twe:classId>C000050275</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>INFLATION PROTECTION PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000018228</twe:seriesId>
              <twe:classInfo>
                <twe:className>Inflation Protection Portfolio</twe:className>
                <twe:classId>C000050276</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>LARGE CAP BLEND PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000018229</twe:seriesId>
              <twe:classInfo>
                <twe:className>Large Cap Blend Portfolio</twe:className>
                <twe:classId>C000050277</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>RESEARCH INTERNATIONAL CORE PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000018230</twe:seriesId>
              <twe:classInfo>
                <twe:className>Research International Core Portfolio</twe:className>
                <twe:classId>C000050278</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>INDEX 600 STOCK PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000018231</twe:seriesId>
              <twe:classInfo>
                <twe:className>Index 600 Stock Portfolio</twe:className>
                <twe:classId>C000050279</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>EMERGING MARKETS EQUITY PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000018232</twe:seriesId>
              <twe:classInfo>
                <twe:className>Emerging Markets Equity Portfolio</twe:className>
                <twe:classId>C000050280</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>SHORT-TERM BOND PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000018233</twe:seriesId>
              <twe:classInfo>
                <twe:className>Short-Term Bond Portfolio</twe:className>
                <twe:classId>C000050281</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>LONG-TERM US GOVERNMENT BOND PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000018234</twe:seriesId>
              <twe:classInfo>
                <twe:className>Long-Term US Government Bond Portfolio</twe:className>
                <twe:classId>C000050282</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
            <twe:rptSeriesClassInfo>
              <twe:seriesName>MULTI-SECTOR BOND PORTFOLIO</twe:seriesName>
              <twe:seriesId>S000018235</twe:seriesId>
              <twe:classInfo>
                <twe:className>Multi-Sector Bond Portfolio</twe:className>
                <twe:classId>C000050283</twe:classId>
              </twe:classInfo>
            </twe:rptSeriesClassInfo>
          </twe:reportSeriesClass>
        </twe:item2>
        <twe:item3>
          <twe:investmentCompActFileNo>811-3990</twe:investmentCompActFileNo>
          <twe:securitiesActFileNumbers>
            <twe:securitiesActFileNo>
              <twe:fileNumber>002-89971</twe:fileNumber>
            </twe:securitiesActFileNo>
          </twe:securitiesActFileNumbers>
        </twe:item3>
        <twe:item4>
          <twe:lastDayOfFiscalYear>12/31/2022</twe:lastDayOfFiscalYear>
          <twe:isThisFormBeingFiledLate>false</twe:isThisFormBeingFiledLate>
          <twe:isThisTheLastTimeIssuerFilingThisForm>false</twe:isThisTheLastTimeIssuerFilingThisForm>
        </twe:item4>
        <twe:item5>
          <twe:aggregateSalePriceOfSecuritiesSold>330229799.00</twe:aggregateSalePriceOfSecuritiesSold>
          <twe:aggregatePriceOfSecuritiesRedeemedOrRepurchasedInFiscalYear>636657126.00</twe:aggregatePriceOfSecuritiesRedeemedOrRepurchasedInFiscalYear>
          <twe:aggregatePriceOfSecuritiesRedeemedOrRepurchasedAnyPrior>276193184.00</twe:aggregatePriceOfSecuritiesRedeemedOrRepurchasedAnyPrior>
          <twe:totalAvailableRedemptionCredits>912850310.00</twe:totalAvailableRedemptionCredits>
          <twe:netSales>0.00</twe:netSales>
          <twe:redemptionCreditsAvailableForUseInFutureYears>(582620511.00)</twe:redemptionCreditsAvailableForUseInFutureYears>
          <twe:multiplierForDeterminingRegistrationFee>0.0001102</twe:multiplierForDeterminingRegistrationFee>
          <twe:registrationFeeDue>0.00</twe:registrationFeeDue>
        </twe:item5>
        <twe:item6/>
        <twe:item7>
          <twe:interestDue>0</twe:interestDue>
        </twe:item7>
        <twe:item8>
          <twe:totalOfRegistrationFeePlusAnyInterestDue>0.00</twe:totalOfRegistrationFeePlusAnyInterestDue>
        </twe:item8>
        <twe:item9/>
        <twe:signature>
          <twe:signature>Linda Wisniewski</twe:signature>
          <twe:nameAndTitle>Linda Wisniewski Assistant Controller, Northwestern Mutual Series Fund, Inc.</twe:nameAndTitle>
          <twe:signatureDate>03/20/2023</twe:signatureDate>
        </twe:signature>
      </twe:annualFilingInfo>
    </twe:annualFilings>
  </twe:formData>
</twe:edgarSubmission>
