X0101 EFFECT 33 LIVE 2015-10-27 10:00:00

N-14

0000741375 MORGAN STANLEY INSTITUTIONAL FUND TRUST 333-206028 0000741375 MORGAN STANLEY INSTITUTIONAL FUND TRUST S000004119 Limited Duration Portfolio C000011550 Class I Shares 0000876162 MORGAN STANLEY LTD DURATION US GOVERNMENT TRUST S000004077 MORGAN STANLEY LTD DURATION US GOVERNMENT TRUST C000126927 Class I 0000741375 MORGAN STANLEY INSTITUTIONAL FUND TRUST S000004119 Limited Duration Portfolio C000052876 Class A Shares 0000876162 MORGAN STANLEY LTD DURATION US GOVERNMENT TRUST S000004077 MORGAN STANLEY LTD DURATION US GOVERNMENT TRUST C000011413 Advisor Class