-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 N/stur2gAaVg5gqcrAybcImBeRrtXFBpwTlIacIE2D9vQHP5s5S00H7Jkll8QOFn
 y+sLCgVAOdwKNoB08irOfQ==

<SEC-DOCUMENT>0000914317-08-000382.txt : 20080206
<SEC-HEADER>0000914317-08-000382.hdr.sgml : 20080206
<ACCEPTANCE-DATETIME>20080206115423
ACCESSION NUMBER:		0000914317-08-000382
CONFORMED SUBMISSION TYPE:	5
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20071231
FILED AS OF DATE:		20080206
DATE AS OF CHANGE:		20080206

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			HICKS KERMIT G
		CENTRAL INDEX KEY:			0001204473

	FILING VALUES:
		FORM TYPE:		5
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-12826
		FILM NUMBER:		08580300

	BUSINESS ADDRESS:	
		STREET 1:		C/O FIRST NATIONAL BANK OF GREENCASTLE
		STREET 2:		P O BOX 8
		CITY:			GREENCASTLE
		STATE:			PA
		ZIP:			17225
		BUSINESS PHONE:		7175972137

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TOWER BANCORP INC
		CENTRAL INDEX KEY:			0000740942
		STANDARD INDUSTRIAL CLASSIFICATION:	STATE COMMERCIAL BANKS [6022]
		IRS NUMBER:				251445946
		STATE OF INCORPORATION:			PA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		40 CENTER SQ
		STREET 2:		P O BOX 8
		CITY:			GREENCASTLE
		STATE:			PA
		ZIP:			17225
		BUSINESS PHONE:		7175972137

	MAIL ADDRESS:	
		STREET 1:		40 CENTER SQU
		CITY:			GREENCASTLE
		STATE:			PA
		ZIP:			17225
</SEC-HEADER>
<DOCUMENT>
<TYPE>5
<SEQUENCE>1
<FILENAME>form5-89348_khex.xml
<DESCRIPTION>5
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>5</documentType>

    <periodOfReport>2007-12-31</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <form3HoldingsReported>0</form3HoldingsReported>

    <form4TransactionsReported>0</form4TransactionsReported>

    <issuer>
        <issuerCik>0000740942</issuerCik>
        <issuerName>TOWER BANCORP INC</issuerName>
        <issuerTradingSymbol>TOBC.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001204473</rptOwnerCik>
            <rptOwnerName>HICKS KERMIT G</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>P.O. BOX 280</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>GREENCASTLE</rptOwnerCity>
            <rptOwnerState>PA</rptOwnerState>
            <rptOwnerZipCode>17225</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chairman of Board</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Tower Bancorp, Inc.</value>
            </securityTitle>
            <transactionDate>
                <value>2007-12-27</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>5</transactionFormType>
                <transactionCode>W</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>427</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Tower Bancorp, Inc.</value>
            </securityTitle>
            <transactionDate>
                <value>2007-12-24</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>5</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>792</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>41.1126</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>28784</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <ownerSignature>
        <signatureName>/s/ Kermit G. Hicks</signatureName>
        <signatureDate>2008-02-06</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----