X0306 4 2017-02-02 0 0000737207 Marina Biotech, Inc. MRNA 0001559647 Ramelli Joseph W. C/O MARINA BIOTECH, INC. 17870 CASTLETON ST., STE. 250 CITY OF INDUSTRY CA 91748 0 1 0 0 Chief Executive Officer Common Stock 2017-02-02 4 A 0 100000 0 A 307603 D Represents restricted shares of common stock awarded to the reporting person on February 2, 2017 pursuant to the employment letter dated February 2, 2017 between the reporting person and the issuer. Such restricted shares shall vest upon the first execution and delivery by the issuer following the date of the employment letter of a definitive agreement involving the licensing by the issuer its Smarticles-based liposomal delivery technology. The restricted shares were issued under the issuer's 2014 Long-Term Incentive Plan. /s/ Joseph W. Ramelli 2017-02-03