X0202 4 2008-06-10 0 0000737207 MDRNA, Inc. MRNA 0001249004 YORK BRUCE R 3830 MONTE VILLA PKWY BOTHELL WA 98021 0 1 0 0 CFO and Secretary MDRNA, Inc. Common Stock 35232 D MDRNA, Inc. Common Stock Options 1.19 2008-06-10 4 A 0 120000 1.19 A 2018-06-12 Common Stock 120000 149000 D MDRNA, Inc. Common Stock Options 2.19 2008-06-10 4 A 0 120000 2.19 A 2018-06-12 Common Stock 120000 269000 D MDRNA, Inc. Common Stock Options 3.19 2008-06-10 4 A 0 120000 3.19 A 2018-06-12 Cpmmon Stock 120000 389000 D On June 10, 2008, the reporting person was granted incentive stock options to purchase 197,999 shares of common stock and non-qualified options to purchase 162,001 shares of common stock pursuant to the 2008 Stock Incentive Plan of MDRNA, Inc. The options vest in three equal annual installments over three years beginning on June 10, 2009. The exercise price of the options which vest on June 10, 2009 is the market closing price on June 10, 2008; for each following year, there is a $1.00 increase in exercise price per year. /s/ Dr. Steven Quay Attorney In Fact 2008-06-12