X0202 3 2007-10-04 0 0000737207 NASTECH PHARMACEUTICAL CO INC NSTK 0001413755 Costantino Henry R 3830 MONTE VILLA PARKWAY BOTHELL WA 98021 0 1 0 0 Chief Scientific Officer Nastech Pharmaceutical Company Inc Common Stock 369 D Nastech Pharmaceutical Company Inc Common Stock 215 D Nastech Pharmaceutical Company Inc Common Stock 304 D Nastech Pharmaceutical Company Inc Common Stock 1434 D Nastech Pharmaceutical Company Inc Common Stock 582 D Nastech Pharmaceutical Company Inc Common Stock 2733 D Nastech Pharmaceutical Company Inc Common Stock 5000 D Nastech Pharmaceutical Company Inc Stock Options 10.24 Nastech Pharmaceutical Company Inc Common Stock 6666 D On February 1, 2005, the reporting person was granted 645 restricted shares of common stock pursuant to the 2004 Stock Incentive Plan of Nastech Pharmaceutical Company Inc. The restricted shares vest in three equal annual installments, beginning on February 1, 2006. Of the 645 restricted shares, 215 are unvested and the remainder have vested as of October 4, 2007. On July 1, 2005, the reporting person was granted 912 restricted shares of common stock pursuant to the 2004 Stock Incentive Plan of Nastech Pharmaceutical Company Inc. The restricted shares vest in three equal annual installments, beginning on July 1, 2006. Of the 912 restricted shares, 304 are unvested and the remainder have vested as of October 4, 2007. On July 14, 2006, the reporting person was granted 2,151 restricted shares of common stock pursuant to the 2004 Stock Incentive Plan of Nastech Pharmaceutical Company Inc. The restricted shares vest in three equal annual installments, beginning on July 14, 2007. Of the 2,151 restricted shares, 1,434 are unvested and the remainder have vested as of October 4, 2007. On February 13, 2007, the reporting person was granted 582 restricted shares of common stock pursuant to the 2004 Stock Incentive Plan of Nastech Pharmaceutical Company Inc. The restricted shares vest in three equal annual installments, beginning on February 13, 2008. On July 2, 2007, the reporting person was granted 2,733 restricted shares of common stock pursuant to the 2004 Stock Incentive Plan of Nastech Pharmaceutical Company Inc. The restricted shares vest in three equal annual installments, beginning on July 2, 2008. On August 2, 2007, the reporting person was granted 5,000 restricted shares of common stock pursuant to the 2004 Stock Incentive Plan of Nastech Pharmaceutical Company Inc. The restricted shares vest in three equal annual installments, beginning on August 2, 2008. On July 21, 2003, the reporting person was granted 20,000 nonqualified stock options to purchase shares of common stock pursuant to the 2000 Nonqualified Stock Option Plan of Nastech Pharmaceutical Company Inc. The options vested over three years as follows: 6,666 on July 21, 2004 and 6,667 on July 21, 2005 and 2006. Of these options, 13,334 have been exercised and 6,666 options are vested and outstanding as of October 4, 2007. The options expire on July 21, 2008. Bruce R. York /s/ Bruce R. York Attorney in Fact 2007-10-09