X0306 4 2017-11-22 0 0000737207 Marina Biotech, Inc. MRNA 0000905536 BLECH ISAAC C/O MARINA BIOTECH, INC. 17870 CASTLETON STREET, SUITE 250 CITY OF INDUSTRY CA 91748 1 0 0 0 Stock Option (Right to Buy) 1.8 2017-11-22 4 A 0 473457 0 A 2017-11-22 Common Stock 473457 473457 D Security granted on November 22, 2017 under the Issuer's 2014 Long-Term Incentive Plan as an initial one-time grant to the Reporting Person in connection with his appointment to the Issuer's Board of Directors on November 22, 2017. The option shall vest in twenty (20) equal (or as nearly equal as possible) quarterly installments beginning December 31, 2017. /s/ Isaac Blech 2017-11-27