Shares | Market Value ($000) | ||
Common Stocks (98.2%) | |||
Belgium (3.2%) | |||
1 | UCB SA | 10,647,286 | 778,743 |
* | Argenx SE | 1,170,371 | 550,521 |
* | Galapagos NV | 1,175,458 | 39,109 |
1,368,373 | |||
Brazil (0.0%) | |||
*,2 | Hapvida Participacoes e Investimentos SA | 8,909,471 | 6,521 |
China (1.2%) | |||
2 | WuXi AppTec Co. Ltd. Class H | 11,971,416 | 143,855 |
* | Legend Biotech Corp. ADR | 1,511,284 | 99,850 |
*,2 | Wuxi Biologics Cayman Inc. | 10,465,200 | 65,070 |
Shandong Weigao Group Medical Polymer Co. Ltd. Class H | 69,910,000 | 64,890 | |
*,3 | Zai Lab Ltd. ADR | 1,995,154 | 50,278 |
* | Zai Lab Ltd. | 16,916,600 | 43,172 |
*,2 | Remegen Co. Ltd. Class H | 4,397,500 | 25,044 |
492,159 | |||
Denmark (2.7%) | |||
* | Genmab A/S | 2,088,852 | 590,483 |
Novo Nordisk A/S Class B | 3,386,878 | 326,753 | |
* | Ascendis Pharma A/S ADR | 1,893,751 | 169,131 |
*,3 | Genmab A/S ADR | 2,285,855 | 64,918 |
1,151,285 | |||
Italy (0.1%) | |||
DiaSorin SpA | 552,359 | 49,504 | |
Japan (8.1%) | |||
Daiichi Sankyo Co. Ltd. | 43,976,590 | 1,133,901 | |
1 | Eisai Co. Ltd. | 19,123,817 | 1,013,148 |
Chugai Pharmaceutical Co. Ltd. | 28,320,400 | 839,886 | |
Otsuka Holdings Co. Ltd. | 7,660,100 | 257,731 | |
Terumo Corp. | 6,976,400 | 190,862 | |
Asahi Intecc Co. Ltd. | 2,023,500 | 34,000 | |
3,469,528 | |||
Switzerland (5.8%) | |||
Novartis AG (Registered) | 21,909,275 | 2,051,137 | |
Alcon Inc. | 3,393,208 | 242,873 | |
* | Sandoz Group AG | 4,472,143 | 116,271 |
Tecan Group AG (Registered) | 236,453 | 68,051 | |
2,478,332 | |||
United Kingdom (6.6%) | |||
AstraZeneca plc | 19,618,370 | 2,456,292 | |
GSK plc | 11,995,095 | 213,834 |
Shares | Market Value ($000) | ||
* | Immunocore Holdings plc ADR | 2,085,568 | 92,599 |
Genus plc | 1,791,160 | 46,593 | |
* | Verona Pharma plc ADR | 1,160,032 | 16,183 |
2,825,501 | |||
United States (70.5%) | |||
Eli Lilly & Co. | 6,162,883 | 3,413,806 | |
UnitedHealth Group Inc. | 6,201,994 | 3,321,540 | |
Merck & Co. Inc. | 20,479,587 | 2,103,254 | |
Pfizer Inc. | 58,865,924 | 1,798,943 | |
Humana Inc. | 2,265,222 | 1,186,274 | |
Elevance Health Inc. | 2,560,815 | 1,152,597 | |
Abbott Laboratories | 11,672,803 | 1,103,664 | |
* | Biogen Inc. | 4,558,453 | 1,082,815 |
Danaher Corp. | 5,113,563 | 981,906 | |
* | Boston Scientific Corp. | 18,544,793 | 949,308 |
Thermo Fisher Scientific Inc. | 2,108,134 | 937,635 | |
* | Alnylam Pharmaceuticals Inc. | 5,524,903 | 838,680 |
Stryker Corp. | 3,019,829 | 816,018 | |
* | Vertex Pharmaceuticals Inc. | 2,140,609 | 775,136 |
* | Regeneron Pharmaceuticals Inc. | 943,378 | 735,731 |
Zoetis Inc. | 4,469,317 | 701,683 | |
HCA Healthcare Inc. | 2,796,119 | 632,314 | |
* | Centene Corp. | 8,903,692 | 614,177 |
* | Edwards Lifesciences Corp. | 9,386,095 | 598,082 |
* | Moderna Inc. | 6,006,382 | 456,245 |
*,1 | Apellis Pharmaceuticals Inc. | 8,783,055 | 427,383 |
Agilent Technologies Inc. | 3,576,445 | 369,697 | |
* | agilon health Inc. | 19,042,628 | 342,767 |
* | IQVIA Holdings Inc. | 1,797,052 | 324,961 |
Laboratory Corp. of America Holdings | 1,485,818 | 296,762 | |
* | Molina Healthcare Inc. | 729,664 | 242,942 |
Teleflex Inc. | 1,217,493 | 224,932 | |
* | Acadia Healthcare Co. Inc. | 3,047,446 | 224,018 |
* | Waters Corp. | 811,122 | 193,477 |
* | Insulet Corp. | 1,457,112 | 193,169 |
* | Illumina Inc. | 1,744,376 | 190,870 |
* | United Therapeutics Corp. | 842,593 | 187,780 |
* | Alkermes plc | 7,675,410 | 185,668 |
* | Blueprint Medicines Corp. | 2,857,677 | 168,203 |
* | Exact Sciences Corp. | 2,624,777 | 161,660 |
* | Sarepta Therapeutics Inc. | 2,283,656 | 153,713 |
* | Karuna Therapeutics Inc. | 900,108 | 149,967 |
* | Align Technology Inc. | 714,731 | 131,932 |
*,1 | REVOLUTION Medicines Inc. | 6,449,517 | 127,700 |
* | Cytokinetics Inc. | 3,334,530 | 116,242 |
* | Vaxcyte Inc. | 2,365,953 | 113,802 |
* | Denali Therapeutics Inc. | 5,100,454 | 96,042 |
* | ImmunoGen Inc. | 6,287,201 | 93,428 |
Encompass Health Corp. | 1,448,032 | 90,589 | |
* | Shockwave Medical Inc. | 425,258 | 87,714 |
* | Roivant Sciences Ltd. | 9,572,139 | 82,703 |
* | Evolent Health Inc. Class A | 3,351,619 | 81,880 |
*,1 | Sage Therapeutics Inc. | 4,304,671 | 80,626 |
* | Rocket Pharmaceuticals Inc. | 4,092,055 | 74,066 |
* | Ionis Pharmaceuticals Inc. | 1,646,123 | 72,874 |
* | Amicus Therapeutics Inc. | 6,120,321 | 67,140 |
* | Prothena Corp. plc | 1,782,583 | 64,993 |
* | Option Care Health Inc. | 2,086,842 | 57,868 |
Shares | Market Value ($000) | ||
* | Celldex Therapeutics Inc. | 2,219,651 | 52,206 |
* | PTC Therapeutics Inc. | 2,749,139 | 51,546 |
* | Surgery Partners Inc. | 2,158,143 | 49,918 |
* | Agios Pharmaceuticals Inc. | 2,179,303 | 45,787 |
* | Syndax Pharmaceuticals Inc. | 3,092,082 | 43,536 |
* | Privia Health Group Inc. | 2,035,900 | 42,795 |
* | Xenon Pharmaceuticals Inc. | 1,281,157 | 39,716 |
* | Intellia Therapeutics Inc. | 1,534,651 | 38,443 |
* | Morphic Holding Inc. | 1,237,989 | 24,698 |
* | TG Therapeutics Inc. | 3,066,304 | 23,703 |
*,3 | RayzeBio Inc. | 1,198,440 | 23,250 |
* | Kymera Therapeutics Inc. | 1,442,019 | 16,828 |
*,3 | MoonLake Immunotherapeutics | 213,700 | 11,072 |
30,140,874 | |||
Total Common Stocks (Cost $28,168,959) | 41,982,077 | ||
Temporary Cash Investments (1.8%) | |||
Money Market Fund (0.1%) | |||
4,5 | Vanguard Market Liquidity Fund, 5.420% | 224,870 | 22,485 |
Face Amount ($000) | |||
Repurchase Agreements (1.7%) | |||
Bank of America Securities, LLC, 5.300%, 11/1/23 (Dated 10/31/23, Repurchase Value $23,804,000, collateralized by U.S. Treasury Note/Bond 4.500%, 7/15/26, with a value of $24,276,000) | 23,800 | 23,800 | |
Bank of Nova Scotia, 5.280%, 11/1/23 (Dated 10/31/23, Repurchase Value $96,214,000, collateralized by U.S. Treasury Bill 0.000%, 1/2/24–6/13/24, and U.S. Treasury Note/Bond 4.125%, 7/31/28, with a value of $98,138,000) | 96,200 | 96,200 | |
Barclays Capital Inc., 5.300%, 11/1/23 (Dated 10/31/23, Repurchase Value $67,010,000, collateralized by U.S. Treasury Note/Bond 2.625%, 7/31/29, with a value of $68,340,000) | 67,000 | 67,000 | |
BNP Paribas Securities Corp., 5.280%, 11/1/23 (Dated 10/31/23, Repurchase Value $73,511,000, collateralized by U.S Treasury Bill 0.000%, 1/2/24, U.S. Treasury Inflation Indexed Note/Bond 5.419%, 7/31/24, and U.S. Treasury Note/Bond 0.500%–4.625%, 11/15/24–8/15/50, with a value of $74,970,000) | 73,500 | 73,500 | |
BNP Paribas Securities Corp., 5.300%, 11/1/23 (Dated 10/31/23, Repurchase Value $72,911,000, collateralized by Fannie Mae 1.820%–6.859%, 12/1/30–10/1/53, Freddie Mac 2.000%–7.043%, 5/1/32–12/1/52, Ginnie Mae 2.500%–7.000%, 2/15/31–9/20/63, U.S. Treasury Bill 0.000%, 8/8/24–9/5/24, and U.S. Treasury Note/Bond 0.500%–4.125%, 4/30/26–10/31/27, with a value of $74,358,000) | 72,900 | 72,900 | |
Credit Agricole Securities, 5.280%, 11/1/23 (Dated 10/31/23, Repurchase Value $87,713,000, collateralized by U.S. Treasury Inflation Indexed Note/Bond 0.125%, 10/15/26, with a value of $89,454,000) | 87,700 | 87,700 | |
HSBC Bank USA, 5.280%, 11/1/23 (Dated 10/31/23, Repurchase Value $49,007,000, collateralized by U.S. Treasury Bill 0.000%, 2/13/24–2/22/24, with a value of $49,980,000) | 49,000 | 49,000 |
Face Amount ($000) | Market Value ($000) | ||
HSBC Bank USA, 5.300%, 11/1/23 (Dated 10/31/23, Repurchase Value $59,709,000, collateralized by Fannie Mae 1.500%–6.500%, 9/1/29–5/1/58, Freddie Mac 2.000%–6.000%, 8/1/34–3/1/53, U.S. Treasury Bill 0.000%, 5/16/24, U.S. Treasury Inflation Indexed Note/Bond 2.375%–5.522%, 10/31/24–1/15/25, and U.S. Treasury Note/Bond 0.250%–2.500%, 11/15/23–12/31/24, with a value of $60,894,000) | 59,700 | 59,700 | |
JP Morgan Securities LLC, 5.290%, 11/1/23 (Dated 10/31/23, Repurchase Value $63,009,000, collateralized by U.S. Treasury Bill 0.000%, 12/19/23–3/21/24, and U.S. Treasury Note/Bond 0.125%–4.500%, 11/15/23–2/15/47, with a value of $64,260,000) | 63,000 | 63,000 | |
Natixis SA, 5.280%, 11/1/23 (Dated 10/31/23, Repurchase Value $48,507,000, collateralized by Federal Home Loan Bank 2.840%, 1/27/42, U.S. Treasury Inflation Indexed Note/Bond 0.125%–1.625%, 10/15/27–2/15/53, and U.S. Treasury Note/Bond 0.750%–4.500%, 7/31/24–5/15/46, with a value of $49,470,000) | 48,500 | 48,500 | |
Nomura International plc, 5.280%, 11/1/23 (Dated 10/31/23, Repurchase Value $57,708,000, collateralized by U.S. Treasury Inflation Indexed Note/Bond 0.125%–1.125%, 1/15/32–1/15/33, and U.S. Treasury Note/Bond 0.250%–4.000%, 12/15/24–4/30/30, with a value of $58,933,000) | 57,700 | 57,700 | |
RBC Capital Markets LLC, 5.290%, 11/1/23 (Dated 10/31/23, Repurchase Value $49,507,000, collateralized by U.S. Treasury Note/Bond 3.125%–3.625%, 8/31/27–3/31/28, with a value of $50,490,000) | 49,500 | 49,500 | |
748,500 | |||
Total Temporary Cash Investments (Cost $770,983) | 770,985 | ||
Total Investments (100.0%) (Cost $28,939,942) | 42,753,062 | ||
Other Assets and Liabilities—Net (0.0%) | 14,092 | ||
Net Assets (100%) | 42,767,154 | ||
Cost is in $000. |
* | Non-income-producing security. |
1 | Considered an affiliated company of the fund as the fund owns more than 5% of the outstanding voting securities of such company. |
2 | Security exempt from registration under Rule 144A of the Securities Act of 1933. Such securities may be sold in transactions exempt from registration, normally to qualified institutional buyers. At October 31, 2023, the aggregate value was $240,490,000, representing 0.6% of net assets. |
3 | Includes partial security positions on loan to broker-dealers. The total value of securities on loan is $22,152,000. |
4 | Affiliated money market fund available only to Vanguard funds and certain trusts and accounts managed by Vanguard. Rate shown is the 7-day yield. |
5 | Collateral of $22,393,000 was received for securities on loan. |
ADR—American Depositary Receipt. |
Level 1 ($000) | Level 2 ($000) | Level 3 ($000) | Total ($000) | |
Investments | ||||
Assets | ||||
Common Stocks—North and South America | 30,147,395 | — | — | 30,147,395 |
Common Stocks—Other | 492,959 | 11,341,723 | — | 11,834,682 |
Temporary Cash Investments | 22,485 | 748,500 | — | 770,985 |
Total | 30,662,839 | 12,090,223 | — | 42,753,062 |
Current Period Transactions | ||||||||
Jan. 31, 2023 Market Value ($000) | Purchases at Cost ($000) | Proceeds from Securities Sold ($000) | Realized Net Gain (Loss) ($000) | Change in Unrealized App. (Dep.) ($000) | Income ($000) | Capital Gain Distributions Received ($000) | Oct. 31, 2023 Market Value ($000) | |
2seventy bio Inc. | 27,835 | — | 8,155 | (166,975) | 147,295 | — | — | — |
Agios Pharmaceuticals Inc. | 151,775 | — | 68,756 | (135,374) | 98,142 | — | — | NA1 |
Apellis Pharmaceuticals Inc. | NA2 | 244,635 | 23,539 | 6,741 | 29,603 | — | — | 427,383 |
Eisai Co. Ltd. | 1,152,216 | 47,189 | 23,329 | 310 | (163,238) | 10,564 | — | 1,013,148 |
Ironwood Pharmaceuticals Inc. Class A | 125,592 | — | 113,327 | (6,333) | (5,932) | — | — | — |
REVOLUTION Medicines Inc. | NA2 | 81,752 | — | — | (34,034) | — | — | 127,700 |
Sage Therapeutics Inc. | NA2 | 95,967 | — | — | (77,704) | — | — | 80,626 |
UCB SA | 896,839 | — | 21,218 | (4,083) | (92,795) | 11,227 | — | 778,743 |
Vanguard Market Liquidity Fund | 669 | NA3 | NA3 | (2) | 1 | — | — | 22,485 |
Total | 2,354,926 | 469,543 | 258,324 | (305,716) | (98,662) | 21,791 | — | 2,450,085 |
1 | Not applicable—at October 31, 2023, the security was still held, but the issuer was no longer an affiliated company of the fund. |
2 | Not applicable—at January 31, 2023, the issuer was not an affiliated company of the fund. |
3 | Not applicable—purchases and sales are for temporary cash investment purposes. |