Fair Value Measurements - Additional Information (Detail) - USD ($)			12 Months Ended
	Sep. 20, 2021	Sep. 16, 2021	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Jul. 31, 2019
Summary Of Significant Accounting Policies [Line Items]
Cash and cash equivalents			$ 603,814,000	$ 717,292,000	$ 528,392,000
Business combination contingent consideration			$ 5,900,000
0.375% Convertible Senior Notes due 2024
Summary Of Significant Accounting Policies [Line Items]
Principal amount						$ 287,500,000
Notes, due date			Jul. 15, 2024
Notes, frequency of periodic payment			semi-annually
Total convertible senior notes			$ 255,300,000	243,700,000
Fair value of convertible senior notes			678,500,000	501,000,000.0
Senior convertible notes					0.375%	0.375%
Avitide Inc.
Summary Of Significant Accounting Policies [Line Items]
Upfront payment	$ 150,000,000.0	$ 75,000,000.0
Business combination contingent consideration		$ 88,400,000	88,373,000
Additional undiscounted in contingent consideration earnout payments	$ 125,000.0
Money Market | Level1
Summary Of Significant Accounting Policies [Line Items]
Cash and cash equivalents			$ 460,900,000	$ 549,000.0