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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 cGDzlkf9+j70l5lMZs3f2g==

<SEC-DOCUMENT>0001209191-06-018933.txt : 20060320
<SEC-HEADER>0001209191-06-018933.hdr.sgml : 20060320
<ACCEPTANCE-DATETIME>20060320185659
ACCESSION NUMBER:		0001209191-06-018933
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20060316
FILED AS OF DATE:		20060320
DATE AS OF CHANGE:		20060320

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OSI PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000729922
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				133159796
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		41 PINELAWN ROAD
		CITY:			MELVILLE
		STATE:			NY
		ZIP:			11747
		BUSINESS PHONE:		631-962-2000

	MAIL ADDRESS:	
		STREET 1:		41 PINELAWN ROAD
		CITY:			MELVILLE
		STATE:			NY
		ZIP:			11747

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ONCOGENE SCIENCE INC
		DATE OF NAME CHANGE:	19920703

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			STEVENSON KATHARINE BERGHUIS
		CENTRAL INDEX KEY:			0001232227

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-15190
		FILM NUMBER:		06699760

	BUSINESS ADDRESS:	
		STREET 1:		C/O NORTEL NETWORKS
		STREET 2:		8200 DIXIE ROAD STE 100
		CITY:			BRAMPTON ONTARIO
		STATE:			A6
		ZIP:			L6T 5P6
		BUSINESS PHONE:		9058631160

	MAIL ADDRESS:	
		STREET 1:		C/O NORTEL NETWORKS CORPORATION
		STREET 2:		8200 DIXIE ROAD STE 100
		CITY:			BRAMPTON ONTARIO
		STATE:			A6
		ZIP:			L6T 5P6
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2006-03-16</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000729922</issuerCik>
        <issuerName>OSI PHARMACEUTICALS INC</issuerName>
        <issuerTradingSymbol>OSIP</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001232227</rptOwnerCik>
            <rptOwnerName>STEVENSON KATHARINE BERGHUIS</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O OSI PHARMACEUTICALS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>41 PINELAWN ROAD</rptOwnerStreet2>
            <rptOwnerCity>MELVILLE</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>11747</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2006-03-16</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>357</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3490</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Reflects a grant of restricted stock under the Amended and Restated Stock Incentive Plan, which vests over a three-month period in equal monthly increments.  The grant is exempt under Rule 16b-3.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Michael G. Atieh by Power of Attorney</signatureName>
        <signatureDate>2006-03-20</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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