X0202 4 2005-10-20 0 0000729922 OSI PHARMACEUTICALS INC OSIP 0001314821 LUNDEMOSE ANKER MD, PH.D, DSC C/O OSI PHARMACEUTICALS, INC. 58 SOUTH SERVICE ROAD, SUITE 110 MELVILLE NY 11747 0 1 0 0 Exec. VP & Pres. OSI Prosidion Common Stock 2005-10-20 4 A 0 1700 21.99 A 15068 D The reporting person purchased the shares directly from the Issuer pursuant to a resolution by the Board of Directors of the Issuer established on October 17, 2005 authorizing the sale of shares of OSI common stock at Fair Market Value to directors and executive officers of the Issuer under the Issuer's Amended and Restated Stock Incentive Plan. Michael G. Atieh by Power of Attorney 2005-10-24