X0202 4 2005-05-31 0 0000729922 OSI PHARMACEUTICALS INC OSIP 0001072501 ATIEH MICHAEL G C/O OSI PHARMACEUTICALS, INC. 58 SOUTH SERVICE ROAD, SUITE 110 MELVILLE NY 11747 0 1 0 0 Exec. VP & CFO Common Stock 2005-05-31 4 D 0 571 0.00 D 3311 D Common Stock 2005-06-01 4 A 0 15000 0.00 A 18311 D Stock Option (Right to Buy) 37.20 2005-05-31 4 A 0 150000 0.00 A 2006-05-31 2015-05-30 Common Stock 150000 150000 D Reflects a partial forfieture of restricted stock in the Stock Purchase Plan for Non-Employee Directors. Not applicable. Reflects a grant of restricted stock under the Amended and Restated Stock Incentive Plan, which vests over five years in equal annual increments and any unvested shares are subject to forfieture upon termination of the officer's services to the Issuer prior to the end of the five-year term. The grant is exempt under Rule 16b-3. One third of the stock option will become exercisable one year after the date of the grant and the remainder will vest ratably on a monthly basis over the succeeding 48 months. The stock option was granted pursuant to one of the Issuer's stock incentive plans and is exempt under Rule 16b-3. Includes only options with the same termination date. Michael G. Atieh 2005-06-01