X0202 4 2005-04-01 0 0000729922 OSI PHARMACEUTICALS INC OSIP 0001238971 RICHMOND MARK C/O OSI PHARMACEUTICALS, INC. 58 SOUTH SERVICE ROAD, SUITE 110 MELVILLE NY 11747 1 0 0 0 Common Stock 2005-04-01 4 M 0 1500 16.813 A 5075 D Common Stock 2005-04-01 4 S 0 1500 41.40 D 3575 D Stock Option (Right to Buy) 16.813 2005-04-01 4 M 0 1500 0.00 D 2000-04-10 2010-04-09 Common Stock 1500 27500 D The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. Exercisable as to 25,000 shares on 04/10/2000 and the remainder on 04/10/2001. The stock option was granted pursuant to one of the Issuer's incentive and non-qualified stock option plans and is exempt under Rule 16b-3. Includes only options with the same termination date. Robert L. Van Nostrand by Power of Attorney 2005-04-04