X0202 4 2004-11-19 0 0000729922 OSI PHARMACEUTICALS INC OSIP 0001220050 SIMON ROBERT L C/O OSI PHARMACEUTICALS, INC. 58 SOUTH SERVICE ROAD, SUITE 110 MELVILLE NY 11747 0 1 0 0 VP, Global Reg. Affairs & CMC Common Stock 2004-11-19 4 A 0 10 58.16 A 3415 D Robert L. Van Nostrand by Power of Attorney 2004-12-03