X0202 4 2004-11-19 0 0000729922 OSI PHARMACEUTICALS INC OSIP 0001220049 ONETTO NICOLE C/O OSI PHARMACEUTICALS, INC. 58 SOUTH SERVICE ROAD, SUITE 110 MELVILLE NY 11747 0 1 0 0 Exec.VP& Chief Medical Officer Common Stock 2004-11-19 4 A 0 10 58.16 A 4544 D Common Stock 2004-12-01 4 M 0 900 30.74 A 5444 D Common Stock 2004-12-01 4 S 0 15 47.95 D 5429 D Common Stock 2004-12-01 4 S 0 76 47.97 D 5353 D Common Stock 2004-12-01 4 S 0 46 47.98 D 5307 D Common Stock 2004-12-01 4 S 0 25 47.99 D 5282 D Common Stock 2004-12-01 4 S 0 46 48.00 D 5236 D Common Stock 2004-12-01 4 S 0 61 48.01 D 5175 D Common Stock 2004-12-01 4 S 0 46 48.02 D 5129 D Common Stock 2004-12-01 4 S 0 10 48.03 D 5119 D Common Stock 2004-12-01 4 S 0 41 48.29 D 5078 D Common Stock 2004-12-01 4 S 0 88 48.37 D 4990 D Common Stock 2004-12-01 4 S 0 46 48.40 D 4944 D Common Stock 2004-12-01 4 S 0 10 48.41 D 4934 D Common Stock 2004-12-01 4 S 0 3 48.45 D 4931 D Common Stock 2004-12-01 4 S 0 112 48.50 D 4819 D Common Stock 2004-12-01 4 S 0 92 48.57 D 4727 D Common Stock 2004-12-01 4 S 0 51 48.58 D 4676 D Common Stock 2004-12-01 4 S 0 5 48.60 D 4671 D Common Stock 2004-12-01 4 S 0 5 48.64 D 4666 D Common Stock 2004-12-01 4 S 0 92 48.65 D 4574 D Common Stock 2004-12-01 4 S 0 25 48.66 D 4549 D Common Stock 2004-12-01 4 S 0 5 48.74 D 4544 D Stock Option (Right to Buy) 30.74 2004-12-01 4 M 0 900 0.00 D 2004-06-25 2013-06-24 Common Stock 900 42800 D The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. One third of the stock option became exercisable one year after the date of the grant and the remainder vested ratably on a monthly basis over the succeeding 24 months. The stock option was granted pursuant to one of the Issuer's incentive and non-qualified stock option plans and is exempt under Rule 16b-3. Includes only options with the same termination date. Robert L. Van Nostrand by Power of Attorney 2004-12-03