X0202 4 2004-08-19 0 0000729922 OSI PHARMACEUTICALS INC OSIP 0001238970 WHITE JOHN P C/O OSI PHARMACEUTICALS, INC. 58 SOUTH SERVICE ROAD, SUITE 110 MELVILLE NY 11747 1 0 0 0 Common Stock 2004-08-19 4 M 0 10000 3.625 A 32890 D Common Stock 2004-08-19 4 S 0 3500 58.10 D 29390 D Common Stock 2004-08-19 4 S 0 100 58.13 D 29290 D Common Stock 2004-08-19 4 S 0 1200 58.15 D 28090 D Common Stock 2004-08-19 4 S 0 100 58.16 D 27990 D Common Stock 2004-08-19 4 S 0 2100 58.25 D 25890 D CommonStock 2004-08-19 4 S 0 3000 58.27 D 22890 D Common Stock 3.625 2004-08-19 4 M 0 10000 0.00 D 2000-03-24 2009-03-24 Common Stock 10000 0 D One third of the stock option became exercisable one year after the date of the grant and the remainder vested ratably on a monthly basis over the succeeding 24 months. The stock option was granted pursuant to one of the Issuer's incentive and non-qualified stock option plans and is exempt under Rule 16b-3. Includes only options with the same termination date. Robert L. Van Nostrand by Power of Attorney 2004-08-20