X0202 4 2004-07-01 0 0000729922 OSI PHARMACEUTICALS INC OSIP 0001225199 GODDARD COLIN C/O OSI PHARMACEUTICALS, INC. 58 SOUTH SERVICE ROAD, SUITE 110 MELVILLE NY 11747 1 1 0 0 Chief Executive Officer Common Stock 2004-07-01 4 M 0 6675 5.25 A 40874 D Common Stock 2004-07-01 4 S 0 1084 69.52 D 39790 D Common Stock 2004-07-01 4 S 0 4920 69.95 D 34870 D Common Stock 2004-07-01 4 S 0 510 69.96 D 34360 D Common Stock 2004-07-01 4 S 0 107 69.97 D 34253 D Common Stock 2004-07-01 4 S 0 54 70.00 D 34199 D Stock Option (Right to Buy) 5.25 2004-07-01 4 M 0 6675 0.00 D 1999-06-18 2008-06-17 Common Stock 6675 29325 D The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. One third of the stock option became exercisable one year after the date of the grant and the remainder vests ratably on a monthly basis over the succeeding 24 months. The stock option was granted pursuant to one of the Issuer's incentive and non-qualified stock option plans and is exempt under Rule 16b-3. Includes only options with the same termination date. Robert L. Van Nostrand by Power of Attorney 2004-07-02