X0202 4 2004-06-01 0 0000729922 OSI PHARMACEUTICALS INC OSIP 0001220024 AMPER LINDA E C/O OSI PHARMACEUTICALS, INC. 58 SOUTH SERVICE ROAD, SUITE 110 MELVILLE NY 11747 0 1 0 0 VP Bus. Administration & HR Common Stock 2004-06-01 4 M 0 467.0000 21.5500 A 467.0000 D Common Stock 2004-06-01 4 S 0 161.0000 81.0000 D 306.0000 D Common Stock 2004-06-01 4 S 0 49.0000 81.0558 D 257.0000 D Common Stock 2004-06-01 4 S 0 6.0000 81.2000 D 251.0000 D Common Stock 2004-06-01 4 S 0 49.0000 81.3000 D 202.0000 D Common Stock 2004-06-01 4 S 0 30.0000 81.3381 D 172.0000 D Common Stock 2004-06-01 4 S 0 105.0000 81.5000 D 67.0000 D Common Stock 2004-06-01 4 S 0 6.0000 81.5200 D 61.0000 D Common Stock 2004-06-01 4 S 0 23.0000 81.5533 D 38.0000 D Common Stock 2004-06-01 4 S 0 28.0000 81.7000 D 10.0000 D Common Stock 2004-06-01 4 S 0 6.0000 81.8000 D 4.0000 D Common Stock 2004-06-01 4 S 0 4.0000 81.8100 D 0 D Stock Option (Right to Buy) 21.5500 2004-06-01 4 M 0 467.0000 0 D 2003-06-12 2012-06-11 Common Stock 467.0000 5596.0000 D The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 18, 2003. One third of the stock option became exercisable one year after the date of the grant and the remainder vested ratably on a monthly basis over the succeeding 24 months. The stock option was granted pursuant to one of the Issuer's incentive and non-qualified stock option plans and is exempt under Rule 16b-3. Includes only options with the same termination date. Robert L. Van Nostrand by Power of Attorney 2004-06-03