X0202 4 2004-05-03 0 0000729922 OSI PHARMACEUTICALS INC OSIP 0001225198 VAN NOSTRAND ROBERT L C/O OSI PHARMACEUTICALS, INC. 58 SOUTH SERVICE ROAD, SUITE 110 MELVILLE NY 11747 0 1 0 0 VP, & Chief Financial Officer Common Stock 2004-05-03 4 M 0 2750.0000 9.0000 A 7516.0000 D Common Stock 2004-05-03 4 S 0 71.0000 72.5000 D 7445.0000 D Common Stock 2004-05-03 4 S 0 112.0000 72.5143 D 7333.0000 D Common Stock 2004-05-03 4 S 0 48.0000 72.5500 D 7285.0000 D Common Stock 2004-05-03 4 S 0 49.0000 72.6233 D 7236.0000 D Common Stock 2004-05-03 4 S 0 95.0000 72.9250 D 7141.0000 D Common Stock 2004-05-03 4 S 0 321.0000 73.4235 D 6820.0000 D Common Stock 2004-05-03 4 S 0 1492.0000 73.5000 D 5328.0000 D Common Stock 2004-05-03 4 S 0 562.0000 73.5111 D 4766.0000 D Stock Option (Right to Buy) 9.0000 2004-05-03 4 M 0 2750.0000 0 D 1997-06-20 2006-06-19 Common Stock 2750.0000 7905.0000 D One third of the stock option became exercisable one year after the date of the grant and the remainder vested ratably on a monthly basis over the succeeding 24 months. The stock option was granted pursuant to one of the Issuer's incentive and non-qualified stock option plans and is exempt under Rule 16b-3. Includes only options with the same termination date. Robert L. Van Nostrand 2004-05-05