X0201 42004-01-2100000729922OSI PHARMACEUTICALS INC OSIP0001238973FRENCH JOHN H IIC/O OSI PHARMACEUTICALS, INC.58 SOUTH SERVICE ROAD, SUITE 110MELVILLENY117471000Common Stock2004-01-214M02000.00006.5000A23997.0000DCommon Stock2004-01-214S02000.000035.0000D21997.0000DStock Option (Right to Buy)6.50002004-01-214M02000.00000D1998-03-192007-03-18Common Stock2000.00003303.0000DOne third of the stock option became exercisable one year after the date of the grant and the remainder vested ratably on a monthly basis over the succeeding 24 months.The stock option was granted pursuant to one of the Issuer's incentive and non-qualified stock option plans and is exempt under Rule 16b-3.Includes only options with the same termination date.Robert L. Van Nostrand by Power of Attorney2004-01-23