X0201 42003-12-2200000729922OSI PHARMACEUTICALS INC OSIP0001225198VAN NOSTRAND ROBERT LC/O OSI PHARMACEUTICALS, INC.58 SOUTH SERVICE ROAD, SUITE 110MELVILLENY117470100VP, & Chief Financial OfficerCommon Stock2003-12-224M02595.00009.0000A6341.0000DCommon Stock2003-12-224S0275.000030.2000D6066.0000DCommon Stock2003-12-224S01100.000030.2027D4966.0000DCommon Stock2003-12-224S0200.000030.2300D4766.0000DStock Option (Right to Buy)9.00002003-12-224M02595.00000D1997-06-202006-06-20Common Stock2595.000017405.0000DOne third of the stock option became exercisable one year after the date of the grant and the remainder vested ratably on a monthly basis over the succeeding 24 months.The stock option was granted pursuant to one of the Issuer's incentive and non-qualified stock option plans and is exempt under Rule 16b-3.Includes only options with the same termination date.Robert L. Van Nostrand2003-12-22