X0303 4 2010-06-03 0000729922 OSI PHARMACEUTICALS INC OSIP 0001220024 AMPER LINDA E C/O OSI PHARMACEUTICALS, INC. 420 SAW MILL RIVER RD. ARDSLEY NY 10502 1 Sr. VP, Human Resources Common Stock 2010-06-03 4 U 0 4326 57.50 D 14775 D Common Stock 2010-06-03 4 D 0 14775 57.50 D 0 D Stock Option (Right to Buy) 23.83 2010-06-03 4 D 0 3001 57.50 D 2012-11-30 Common Stock 3001 0 D Stock Option (Right to Buy) 37.74 2010-06-03 4 D 0 10000 57.50 D 2013-12-12 Common Stock 10000 0 D Stock Option (Right to Buy) 47.29 2010-06-03 4 D 0 16500 57.50 D 2014-12-11 Common Stock 16500 0 D Stock Option (Right to Buy) 33.62 2010-06-03 4 D 0 36000 57.50 D 2015-12-15 Common Stock 36000 0 D Stock Option (Right to Buy) 35.40 2010-06-03 4 D 0 20000 57.50 D 2019-12-14 Common Stock 20000 0 D Stock Option (Right to Buy) 67.63 2010-06-03 4 D 0 13900 57.50 D 2014-06-16 Common Stock 13900 0 D Represents the number of unvested Restricted Stock Units that were canceled in exchange for a cash payment of $57.50 per unit in accordance with the Agreement and Plan of Merger, dated as of May 16, 2010, among OSI Pharmaceuticals, Inc., Astellas Pharma Inc., Astellas US Holding, Inc. and Ruby Acquisition, Inc. These stock options were canceled in exchange for a cash payment in accordance with the Agreement and Plan of Merger, dated as of May 16, 2010, among OSI Pharmaceuticals, Inc., Astellas Pharma Inc., Astellas US Holding, Inc. and Ruby Acquisition, Inc. The cash payment made with respect to each stock option equals the product of (x) the number of shares issuable upon the exercise of such option multiplied by (y) the excess, if any, of $57.50 over the exercise price per share for such option. These stock options were canceled in accordance with the Agreement and Plan of Merger, dated as of May 16, 2010, among OSI Pharmaceuticals, Inc., Astellas Pharma Inc., Astellas US Holding, Inc. and Ruby Acquisition, Inc. As the exercise price of the options was above $57.50, no cash payment was provided. /s/ Pierre Legault, attorney-in-fact for Dr. Amper 2010-06-07