X0303 4 2008-12-12 0000729922 OSI PHARMACEUTICALS INC OSIP 0001220051 WOOD BARBARA A C/O OSI PHARMACEUTICALS, INC. 41 PINELAWN ROAD MELVILLE NY 11747 1 Sr. V.P. & General Counsel Common Stock 2008-12-12 4 F 0 520 33.39 D 19069 D Common Stock 2008-12-13 4 F 0 473 33.39 D 18596 D Reflects the withholding of shares by the company to satisfy the tax liability upon the vesting of restricted stock. /s/Michael G. Atieh, attorney-in-fact for Ms. Wood 2008-12-16