X0303 4 2008-12-12 0000729922 OSI PHARMACEUTICALS INC OSIP 0001072501 ATIEH MICHAEL G C/O OSI PHARMACEUTICALS, INC. 41 PINELAWN ROAD MELVILLE NY 11747 1 Exec. VP & CFO Common Stock 2008-12-12 4 F 0 880 33.39 D 32447 D Common Stock 2008-12-13 4 F 0 550 33.39 D 31897 D Reflects the withholding of shares by the company to satisfy the tax liability upon the vesting of restricted stock. This Amended Form 4 is being filed to correct an error reported in the original Form 4 filed on November 21, 2008 (the "Original Form 4"). The Original Form 4 incorrectly reported the weighted average sales price at which the securities were sold for this transaction as $39.11. This Amended Form 4 correctly reports the weighted average sales price of shares sold in this transaction. There are no other changes to the Original Form 4. /s/ Michael G. Atieh 2008-12-16