X0303 4 2008-08-01 0000729922 OSI PHARMACEUTICALS INC OSIP 0001206369 KLEIN JOSEPH III C/O OSI PHARMACEUTICALS, INC. 41 PINELAWN ROAD MELVILLE NY 11747 1 Common Stock 2008-08-01 4 S 0 300 52.05 D 14200 D Common Stock 2008-08-01 4 S 0 2200 52.05 D 12000 D Common Stock 2008-08-01 4 S 0 300 52.05 D 11700 D Common Stock 2008-08-01 4 S 0 200 52.50 D 11500 D Common Stock 2008-08-01 4 S 0 200 52.07 D 4800 I By Joseph Klein III 5% Charitable Remainder Unitrust Common Stock 2008-08-01 4 S 0 100 52.05 D 4700 I By Joseph Klein III 5% Charitable Remainder Unitrust Common Stock 2008-08-01 4 S 0 600 52.05 D 4100 I By Joseph Klein III 5% Charitable Remainder Unitrust Common Stock 2008-08-01 4 S 0 100 52.07 D 4000 I By Joseph Klein III 5% Charitable Remainder Unitrust Common Stock 2008-08-01 4 S 0 100 52.07 D 3900 I By Joseph Klein III 5% Charitable Remainder Unitrust Common Stock 2008-08-01 4 S 0 100 52.07 D 3800 I By Joseph Klein III 5% Charitable Remainder Unitrust Common Stock 2008-08-01 4 S 0 100 52.07 D 3700 I By Joseph Klein III 5% Charitable Remainder Unitrust Common Stock 2008-08-01 4 S 0 2800 52.05 D 900 I By Joseph Klein III 5% Charitable Remainder Unitrust Common Stock 2008-08-01 4 S 0 300 52.05 D 600 I By Joseph Klein III 5% Charitable Remainder Unitrust Common Stock 2008-08-01 4 S 0 600 52.05 D 0 I By Joseph Klein III 5% Charitable Remainder Unitrust /s/ Michael G. Atieh, attorney-in-fact for Mr. Klein 2008-08-01