X0303 4 2006-07-14 0000729922 OSI PHARMACEUTICALS INC OSIP 0001072501 ATIEH MICHAEL G C/O OSI PHARMACEUTICALS, INC. 41 PINELAWN ROAD MELVILLE NY 11747 1 Exec. VP & CFO Common Stock 2008-07-24 4 M 0 50000 30.74 A 93327 D Common Stock 2008-07-24 4 S 0 600 51.08 D 92727 D Common Stock 2008-07-24 4 S 0 100 51.06 D 92627 D Common Stock 2008-07-24 4 S 0 1421 51.09 D 91206 D Common Stock 2008-07-24 4 S 0 100 51.22 D 91106 D Common Stock 2008-07-24 4 S 0 200 51.17 D 90906 D Common Stock 2008-07-24 4 S 0 1468 51.16 D 89438 D Common Stock 2008-07-24 4 S 0 1000 51.18 D 88438 D Common Stock 2008-07-24 4 S 0 32 51.20 D 88406 D Common Stock 2008-07-24 4 S 0 900 51.11 D 87506 D Common Stock 2008-07-24 4 S 0 479 51.13 D 87027 D Common Stock 2008-07-24 4 S 0 5200 51.12 D 81827 D Common Stock 2008-07-24 4 S 0 3272 51.10 D 78555 D Common Stock 2008-07-24 4 S 0 800 51.07 D 77755 D Common Stock 2008-07-24 4 S 0 1621 51.05 D 76134 D Common Stock 2008-07-24 4 S 0 600 51.02 D 75534 D Common Stock 2008-07-24 4 S 0 1400 51.03 D 74134 D Common Stock 2008-07-24 4 S 0 1800 51.04 D 72334 D Common Stock 2008-07-24 4 S 0 5254 51.01 D 67080 D Common Stock 2008-07-24 4 S 0 23753 51.00 D 43327 D Stock Option (Right to Buy) 30.74 2008-07-24 4 M 0 50000 0 D 2004-06-25 2013-06-24 Common Stock 50000 0 D Transaction made pursuant to a 10b5-1 plan dated March 10, 2008. One third of the stock options became exercisable one year after the date of the grant and the remainder vested ratably on a monthly basis over the succeeding 24 months. Includes only options with the same termination date. /s/ Barbara A. Wood by power of attorney 2008-07-28