X0303 4 2008-07-10 0000729922 OSI PHARMACEUTICALS INC OSIP 0001206369 KLEIN JOSEPH III C/O OSI PHARMACEUTICALS, INC. 41 PINELAWN ROAD MELVILLE NY 11747 1 Common Stock 2008-07-10 4 M 0 12500 30.39 A 27000 D Common Stock 2008-07-10 4 M 0 750 36.25 A 27750 D Common Stock 2008-07-10 4 S 0 400 45.05 D 27350 D Common Stock 2008-07-10 4 S 0 100 45.08 D 27250 D Common Stock 2008-07-10 4 S 0 100 45.04 D 27150 D Common Stock 2008-07-10 4 S 0 3800 45.00 D 23350 D Common Stock 2008-07-10 4 S 0 700 45.10 D 22650 D Common Stock 2008-07-10 4 S 0 800 45.09 D 21850 D Common Stock 2008-07-10 4 S 0 315 45.16 D 21535 D Common Stock 2008-07-10 4 S 0 100 45.1775 D 21435 D Common Stock 2008-07-10 4 S 0 2300 45.18 D 19135 D Common Stock 2008-07-10 4 S 0 850 45.15 D 18285 D Common Stock 2008-07-10 4 S 0 500 45.17 D 17785 D Common Stock 2008-07-10 4 S 0 1100 45.14 D 16685 D Common Stock 2008-07-10 4 S 0 1785 45.13 D 14900 D Common Stock 2008-07-10 4 S 0 400 45.12 D 14500 D Common Stock 5000 I By Joseph Klein III 5% Charitable Remainder Unitrust Stock Option (Right to Buy) 30.39 2008-07-10 4 M 0 12500 0 D 2007-06-14 2013-06-13 Common Stock 12500 12500 D Stock Option (Right to Buy) 36.25 2008-07-10 4 M 0 750 0 D 2008-06-13 2014-06-12 Common Stock 750 2250 D Transaction made pursuant to a 10b5-1 plan dated March 8, 2008. 25% of the option will become exercisable one year after the date of grant and the remainder will vest ratably on an annual basis over the succeeding 3 years. 25% of the options became exerciseable one year after the date of grant and the remainder will vest ratably on an annual basis over the suceeding 3 years Includes only options with the same termination date. /s/ Michael G. Atieh, attorney-in-fact for Mr. Klein 2008-07-11