X0202 4 2006-12-01 0000729922 OSI PHARMACEUTICALS INC OSIP 0001238974 GRANNER DARYL K C/O OSI PHARMACEUTICALS, INC. 41 PINELAWN ROAD MELVILLE NY 11747 1 Common Stock 2006-12-01 2006-12-01 4 M 0 5415 6.5 A 17360 D Common Stock 2006-12-01 2006-12-01 4 S 0 171 35.76 D 17189 D Common Stock 2006-12-01 2006-12-01 4 S 0 400 35.77 D 16789 D Common Stock 2006-12-01 2006-12-01 4 S 0 100 35.78 D 16689 D Common Stock 2006-12-01 2006-12-02 4 S 0 300 35.79 D 16389 D Common Stock 2006-12-01 2006-12-01 4 S 0 29 35.8 D 16360 D Common Stock 2006-12-01 2006-12-01 4 S 0 200 35.94 D 16160 D Common Stock 2006-12-01 2006-12-01 4 S 0 400 35.95 D 15760 D Common Stock 2006-12-01 2006-12-01 4 S 0 400 35.96 D 15360 D Common Stock 2006-12-01 2006-12-01 4 S 0 300 36.22 D 15060 D Common Stock 2006-12-01 2006-12-01 4 S 0 300 36.24 D 14760 D Common Stock 2006-12-01 2006-12-01 4 S 0 436 36.27 D 14324 D Common Stock 2006-12-01 2006-12-01 4 S 0 500 36.29 D 13824 D Common Stock 2006-12-01 2006-12-01 4 S 0 100 36.3 D 13724 D Common Stock 2006-12-01 2006-12-01 4 S 0 200 36.31 D 13524 D Common Stock 2006-12-01 2006-12-01 4 S 0 164 36.32 D 13360 D Common Stock 2006-12-01 2006-12-01 4 S 0 144 36.1 D 13216 D Common Stock 2006-12-01 2006-12-01 4 S 0 100 36.13 D 13116 D Common Stock 2006-12-01 2006-12-01 4 S 0 1171 36.17 D 11945 D Stock Option (Right to Buy) 6.5 2006-12-01 2006-12-01 4 M 0 5415 0 D 1997-03-19 2007-03-19 Common Stock 5415 0 D Transaction made pursuant to a 10b5-1 plan dated March 16, 2006. Exercisable upon the director's reelection to the Board on March 25, 1998. /s/ Michael G. Atieh, attorney-in-fact for Dr. Granner 2006-12-04