424B3 1 f424b3_051007-biotech.htm BIOTECH

 

PROSPECTUS SUPPLEMENT

 

REGISTRATION NO. 333-89355

(To Prospectus dated February 17, 2006)

 

Filed Pursuant to Rule 424(b)(3)

 

 

 

 

1,000,000,000 Depositary Receipts
Biotech HOLDRS (SM) Trust

 

 

This prospectus supplement supplements information contained in the prospectus dated February 17, 2006 relating to the sale of up to 1,000,000,000 depositary receipts by the Biotech HOLDRS (SM) Trust.

 

The share amounts specified in the table in the “Highlights of Biotech HOLDRS” section of the base prospectus shall be replaced with the following:

 

Name of Company(1)

 

Ticker

 

Share
Amounts

 

Primary
Trading Market

Affymetrix, Inc.

 

AFFX

 

4

 

NASDAQ

Alkermes, Inc.

 

ALKS

 

4

 

NASDAQ

Amgen Inc.

 

AMGN

 

64.48

 

NASDAQ

Applera Corporation—Applied Biosystems Group*

 

ABI

 

18

 

NYSE

Applera Corporation—Celera Genomics Group*

 

CRA

 

4

 

NYSE

Biogen IDEC Inc.

 

BIIB

 

26.95

 

NASDAQ

Enzon Pharmaceuticals, Inc.

 

ENZN

 

3

 

NASDAQ

Genentech, Inc.

 

DNA

 

88

 

NYSE

Genzyme Corporation

 

GENZ

 

14

 

NASDAQ

Gilead Sciences, Inc.

 

GILD

 

32

 

NASDAQ

Human Genome Sciences, Inc.

 

HGSI

 

8

 

NASDAQ

MedImmune, Inc.

 

MEDI

 

15

 

NASDAQ

Millennium Pharmaceuticals, Inc.

 

MLNM

 

12

 

NASDAQ

QLT Inc.

 

QLTI

 

5

 

NASDAQ

Sepracor Inc.

 

SEPR

 

6

 

NASDAQ

Shire p.l.c.

 

SHPGY

 

6.8271

 

NASDAQ

 

* The securities of this company trade as a tracking stock. Please see “Risk Factors” and the business description in Annex A for additional information relating to an investment in tracking stock.

 

(1)          Effective January 30, 2007, as a result of the merger of ICOS Corporation (NASDAQ ticker: “ICOS”), an underlying constituent of the Biotech HOLDRS Trust, and Eli Lilly & Co., ICOS Corporation is no longer an underlying constituent of the Biotech HOLDRS Trust. For each share of ICOS Corporation held, shareholders received $34.00 in cash. For the 4 shares of ICOS Corporation per 100 shares round lot of Biotech HOLDRS, The Bank of New York received $136.00 in cash. The Bank of New York distributed the cash at a rate of $1.3567 per depositary share of Biotech HOLDRS on February 9, 2007. The record date for such distribution was February 7, 2007.

 

The share amounts listed in the table above reflect all previous stock splits, dividends and business combination transactions.

 

The date of this prospectus supplement is March 31, 2007.