X0306 4 2022-08-05 0000728387 Isoray, Inc. ISR 0001709780 Streeter Jennifer 350 HILLS STREET SUITE 106 RICHLAND WA 99354 1 COO & VP of HR Common Stock 2022-08-05 4 M 0 22500 0.33 A 27940 D Stock Options (right to buy) 0.33 2022-08-05 4 M 0 22500 0 D 2032-07-21 Common Stock 452500 0 D 475,000 stock options were granted on 7/21/2022. 25% vested on 7/21/2022 and the remaining 75% will vest over the next three (3) years, commencing on 7/21/2022, until fully vested. The shares exercised on 8/5/2022 represent the shares that vested on 7/21/2022. /s/ Jennifer Streeter 2022-08-10