X0306 4 2021-07-01 0000728387 Isoray, Inc. ISR 0001597792 Vitale Philip J 8849 E. CALLE DE LAS BRISAS SCOTTSDALE AZ 85255 1 Stock Options (right to buy) 0.79 2021-07-01 4 A 0 135000 0 A 2031-07-01 Common Stock 135000 290000 I By Philip James Vitale Rev Living Trust Dtd 11/6/07 One-third vested on 7/1/2021, and the remaining two-thirds will vest over the next two (2) years, commencing on 7/1/2022, until fully vested. /s/ Philip J. Vitale 2021-07-02