Description of Business (Details Textual) - USD ($)	1 Months Ended		3 Months Ended				12 Months Ended
	Jan. 31, 2018	Jun. 26, 2017	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Dec. 31, 2017	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015	Jan. 30, 2019
Description of Business [Line Items]
Royalty Revenues From Sales Percentage							(2.00%)	7.00%
Proceeds from Royalties Received	$ 88,000
Accounts Payable, Current			$ 439,000			$ 225,000	$ 439,000	$ 225,000
Revenues					$ 60,000		6,918,000	8,379,000
Adjustments To Royalties Revenue				$ 280,000				313,000
Accrued Royalties, Current	$ 313,000		439,000		253,000		439,000
Milestone Receivable on Royalties current			7,000,000			0	7,000,000	0
Recoupment For Product Rebates and Returns				280,000
Royalty [Member]
Description of Business [Line Items]
Decreases Of Royalty Revenues							280,000	877,000
Revenues			94,000	94,000	60,000
Merck [Member]
Description of Business [Line Items]
Decreases Of Royalty Revenues				$ 150,000		111,000			$ 564,000	$ 564,000
Accounts Payable, Current			439,000				439,000
Adjustments To Royalties Revenue								88,000
Accrued Royalties, Current					$ 253,000	313,000		313,000
Accrued Royalties Current After Off setting						225,000		225,000
Merck [Member] | Royalty [Member]
Description of Business [Line Items]
Revenues								1,300,000
Nektar Therapeutics Inc [Member]
Description of Business [Line Items]
Milestone Revenue		$ 7,000,000
Milestones receivable						7,000,000		7,000,000
Royalty Revenue Milestones								7,000,000
Contract with Customer, Liability						$ 7,000,000		$ 7,000,000
Servier IPUK Limited [Member]
Description of Business [Line Items]
Royalty Revenue Milestones							7,000,000
Milestone Receivable on Royalties current			7,000,000				7,000,000
Contract with Customer, Liability			$ 7,000,000				$ 7,000,000				$ 7,000,000
Micromet [Member]
Description of Business [Line Items]
Percentage of Royal Milestones Receivable							50.00%