CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Revenues:
Royalties	$ 40,923	$ 44,940	$ 51,408
Sale of in-process research and development	5,000	40,900	0
Contract research and development	1,431	9,273	0
Miscellaneous income	718	2,752	0
Total revenues	48,072	97,865	51,408
Operating expenses:
Research and development – pipeline	40,180	49,883	45,639
Research and development – specialty and contracted services	926	7,135	24,587
General and administrative	17,281	25,439	37,582
General and administrative – contracted services	115	1,957	0
Restructuring charges	6,025	14,026	693
Total operating expenses	64,527	98,440	108,501
Operating loss	(16,455)	(575)	(57,093)
Other income (expense):
Investment income, net	1,735	3,465	4,312
Interest expense	(5,929)	(6,315)	(11,514)
Other-than-temporary impairment loss	0	(896)	0
Other, net	91	1,184	5,008
Loss from continuing operations before income tax expense (benefit)	(20,558)	(3,137)	(59,287)
Income tax expense (benefit)	205	(337)	(2,085)
Loss from continuing operations	(20,763)	(2,800)	(57,202)
Income and gain from discontinued operations, net of income tax	0	180,043	57,885
Net (loss) income	$ (20,763)	$ 177,243	$ 683
Loss per common share - continuing operations Basic and Diluted (in Dollars per share)	$ (0.40)	$ (0.05)	$ (1.26)
Earnings per common share – discontinued operations Basic and Diluted (in Dollars per share)	$ 0	$ 3.08	$ 1.28
(Loss) earnings per common share – net (loss) income Basic and Diluted (in Dollars per share)	$ (0.40)	$ 3.03	$ 0.02
Weighted average shares – basic and diluted (in Shares)	51,910	58,466	45,186