Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Cash flows from operating activities:
Net loss	$ (7,227)	$ (8,795)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	71	73
Amortization of debt discount and issuance costs	742	1,949
Interest expense added to loan principal	2,038	2,062
Interest expense added to lease liability	226	120
Loss on early extinguishment of debt		2,250
Compensation charge for stock and share option awards	1,816	165
Changes in operating assets and liabilities:
(Increase) decrease in accounts receivable	(45)	149
Decrease (increase) in prepaid expenses and other	2,728	(253)
Increase in other assets	(271)	(271)
Increase in accounts payable	414	195
(Decrease) increase in accrued liabilities	(3,127)	876
Net cash used in operating activities	(2,635)	(1,480)
Cash flows from investing activities:
Additions to property, plant and equipment	(116)
Net cash used in investing activities	(116)
Cash flows from financing activities:
Up-front payment related to lease liability		11,509
Debt issuance costs		(102)
Principal payments on long-term debt	(14)	(10,514)
Net cash (used in) provided by financing activities	(14)	893
Net decrease in cash and cash equivalents	(2,765)	(587)
Cash and cash equivalents, beginning of period	12,172	2,690
Cash and cash equivalents, end of period	$ 9,407	$ 2,103