Stockholders' Equity (Details)				1 Months Ended	2 Months Ended	12 Months Ended
	Oct. 29, 2021 shares	Sep. 30, 2021 USD ($) tranche $ / shares shares	Sep. 17, 2021 tranche shares	Sep. 30, 2021 $ / shares shares	Apr. 09, 2021 USD ($)	Dec. 31, 2021 USD ($) $ / shares shares	Dec. 31, 2020 USD ($) payment tranche $ / shares shares	Dec. 31, 2019 USD ($)	May 31, 2021 USD ($)	May 28, 2021
Class of Stock [Line Items]
Share price (dollars per share) | $ / shares						$ 5.22	$ 7.68
Proceeds from issuance of common and preferred stock | $						$ 42,880,000	$ 359,000	$ 1,458,000
Preferred Stock, Par or Stated Value Per Share | $ / shares						$ 0.001	$ 0.001
Stock issued | $						$ 38,902,000	$ 0	$ 0
2.50% Convertible Notes due 2023 | Convertible notes
Class of Stock [Line Items]
Shares issued (shares)						0
2.50% Convertible Notes due 2023 | Convertible notes | Exchange Transactions
Class of Stock [Line Items]
Aggregate principal amount exchanged | $						$ 51,000,000
Stock issued | $						$ 38,900,000
Series A Preferred Stock
Class of Stock [Line Items]
Dividend rate (usd per share) | $ / shares						$ 0.25
Conversion ratio (shares)						1
Sale or merger trigger conversion ratio (shares)						1
Common Shares | Exchange Transactions
Class of Stock [Line Items]
Shares issued (shares)						6,602,974
December 2020 Securities Purchase Agreement | Affiliated Entity
Class of Stock [Line Items]
Sale of stock (in shares)						201,820
Agreement to purchase shares (in shares)							32,000,000
Number of tranches | tranche							3
Proceeds from issuance of common and preferred stock | $		$ 500,000			$ 21,300,000	$ 1,500,000
September 2021 Rescission Agreement | Affiliated Entity
Class of Stock [Line Items]
Agreement to purchase shares (in shares)			2,643,228
Number of tranches | tranche			2
September 2021 Securities Purchase Agreement | Series A Preferred Stock
Class of Stock [Line Items]
Sale of stock (in shares)	1,318,182
Preferred Stock, Par or Stated Value Per Share | $ / shares		$ 0.001		$ 0.001
September 2021 Securities Purchase Agreement | Affiliated Entity
Class of Stock [Line Items]
Number of tranches | tranche		2
Common stock issuable upon conversion of the Series A Preferred Stock (shares)						3,954,546
September 2021 Securities Purchase Agreement | Affiliated Entity | Series A Preferred Stock
Class of Stock [Line Items]
Sale of stock (in shares)				2,636,364
Agreement to purchase preferred shares (in shares)		3,954,546		3,954,546
Share price (dollars per share) | $ / shares		$ 7.70		$ 7.70
Aggregate purchase price | $						$ 30,500,000
Common stock issuable upon conversion of the Series A Preferred Stock (shares)						3,954,546
Certain Directors And Officers Or Affiliates | December 2020 Securities Purchase Agreement | Affiliated Entity
Class of Stock [Line Items]
Agreement to purchase shares (in shares)							4,166,663
Non-affiliate related entities | payment							3
Jack W. Schuler Living Trust | December 2020 Securities Purchase Agreement | Affiliated Entity
Class of Stock [Line Items]
Agreement to purchase shares (in shares)							3,964,843
Aggregate purchase price | $							$ 30,500,000
At-The-Market Equity Sales Agreement
Class of Stock [Line Items]
Aggregate offering price (of up) | $									$ 50,000,000
Commission percentage										3.00%
Sale of stock (in shares)						2,092,497
Aggregate gross proceeds | $						$ 10,900,000