Income Taxes (Tables)

12 Months Ended

Dec. 31, 2019

Income Tax Disclosure [Abstract]

Schedule of Components of Pretax Loss from Operations

The components of the pretax loss from operations for the years ended December 31 are as follows (in thousands):

	2019			2018			2017
U.S. Domestic	$	(70,452	)	$	(67,508	)	$	(46,849	)
Foreign	(13,964		)	(20,607		)	(16,686		)
Net loss before income taxes	$	(84,416	)	$	(88,115	)	$	(63,535	)

Schedule of Provision for Income Taxes

The components of the provision for income taxes for the years ended December 31 is presented in the following table:

	2019			2018		2017
Current:
Federal	$	—		$	—	$	—
State	8			14		—
Foreign	(119		)	197		493
Total current provision	(111		)	211		493
Deferred:
Federal	—			—		—
State	—			—		—
Foreign	—			—		—
Total deferred provision	—			—		—
Total (benefit) provision	$	(111	)	$	211	$	493

Deferred Income Tax Components

Significant components of the Company’s net deferred income taxes for the years ended December 31 are as follows (in thousands):

	2019			2018
Deferred tax assets:
Net operating loss carryforward	$	66,319		$	53,189
Property & equipment	403			648
Inventory	397			395
Stock options	13,217			11,473
Intangible assets, definite-lived	38			40
General business credit	11,306			9,300
Operating Lease Liability - ASC 842	908			—
Other	59			47
Total deferred income tax assets	92,647			75,092
Valuation allowance	(81,946		)	(63,060		)
Deferred tax assets	$	10,701		$	12,032
Deferred income tax liabilities:
Debt amortization	$	(9,793	)	$	(12,032	)
Right of use asset	$	(908	)	$	—
Total deferred income tax liabilities	$	(10,701	)	$	(12,032	)
Net deferred income taxes	$	—		$	—

Effective Tax Rate

The difference between the U.S. federal statutory income tax rate and the Company’s effective tax rate for years ending December 31 is as follows:

	2019		2018		2017
U.S. federal statutory income tax rate	(21.00	)%	(21.00	)%	(34.00	)%
State taxes, net of federal tax benefit	(3.83	)	(3.07	)	(2.62	)
Permanent and other differences	(0.25	)	(0.26	)	(2.31	)
Change in tax rates	0.16		(0.41	)	(1.02	)
Tax rate differential	3.28		4.92		8.99
Tax cuts and jobs act	—		—		38.46
Unrecognized tax benefits	0.79		0.81		1.20
Nondeductible equity and other compensation	1.12		(0.17	)	(4.31	)
Credit for increased research activities	(2.80	)	(3.12	)	(4.42	)
Change in Valuation allowance	22.40		22.54		0.81
	(0.13	)%	0.24	%	0.78	%

Uncertain Tax Positions

The Company's uncertain tax positions at December 31 as follows (in thousands):

	2019			2018			2017
Balance at beginning of year	$	2,983		$	2,141		$	1,101
Increases for prior positions	7			70			97
Increases for current year positions	724			775			943
Other increases	—			—			—
Decreases due to settlements	—			—			—
Expiration of the statute of limitations for the assessment of taxes	—			—			—
Other decreases	(2		)	(3		)	—
Balance at end of year	$	3,712		$	2,983		$	2,141