Income Taxes - Effective Tax Rate (Details)	12 Months Ended
Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Income Tax Disclosure [Abstract]
U.S. federal statutory income tax rate	(34.00%)	(34.00%)	(34.00%)
State taxes, net of federal tax benefit	(1.69%)	(2.93%)	(3.20%)
Permanent and other differences	(0.17%)	0.11%	(0.00%)
Change in tax rates	0.67%	(0.00%)	(0.00%)
Tax rate differential	8.62%	0.42%	(0.00%)
Unrecognized tax benefits	1.09%	0.40%	(0.00%)
Nondeductible equity and other compensation	1.17%	2.86%	3.70%
Limitation on net operating losses due to §382	(0.00%)	(0.00%)	0.50%
Credit for increased research activities	(3.31%)	(2.67%)	(0.80%)
Change in Valuation allowance	28.02%	35.81%	33.80%
Effective tax rate	0.40%	(0.00%)	(0.00%)

Effective Income Tax Rate Reconciliation, Other Permanent Differences, Percent

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Percentage of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to changes in the valuation allowance for deferred tax assets.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations applicable to statutory income tax expense (benefit) outside of the country of domicile.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations applicable to state and local income tax expense (benefit), net of federal tax expense (benefit).

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to income tax contingencies. Includes, but not limited to, domestic tax contingency, foreign tax contingency, state and local tax contingency, and other contingencies.

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