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License Agreements and Grants - Defense Medical Research and Development Program (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended 56 Months Ended
May 31, 2012
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2016
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Offset to research and development project   $ 1,200 $ 647 $ 527  
Defense Medical Research and Development Program          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Total grant funding $ 2,000        
Length of project (months) 35 years        
Offset to research and development project   $ 54 $ 179 $ 221 $ 612