Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenues:
Product revenue	$ 163	$ 76	$ 0
Licensing and royalty revenues	83	71	122
Total revenues	246	147	122
Costs and expenses:
Research and development	28,196	26,022	19,526
Sales, general and administrative	36,200	17,882	10,695
Amortization	11	10	71
Depreciation	2,340	1,782	817
Impairment of intangibles		0	3
Total costs and expenses	66,747	45,696	31,112
Loss from operations	(66,501)	(45,549)	(30,990)
Interest expense and other	(23)	(4)	(7)
Interest and dividend income	494	74	64
Foreign currency exchange loss	(77)	(19)	0
Total other income	394	51	57
Net loss before income taxes	(66,107)	(45,498)	(30,933)
Provision from income taxes	(267)	0	0
Net loss	$ (66,374)	$ (45,498)	$ (30,933)
Basic and diluted net loss per share (dollars per share)	$ (1.29)	$ (1.01)	$ (0.71)
Weighted average shares outstanding (shares)	51,276	44,998	43,626
Other comprehensive loss:
Net loss	$ (66,374)	$ (45,498)	$ (30,933)
Net unrealized loss on available-for-sale investments	(64)	(20)	(15)
Foreign currency translation adjustment	(128)	1	0
Comprehensive loss	$ (66,566)	$ (45,517)	$ (30,948)