STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Revenues:
Product sales	$ 0	$ 0	$ 143	$ 0
Licensing and royalty revenues	20	19	40	33
Total revenues	20	19	183	33
Costs and expenses:
Research and development	8,062	7,126	15,416	12,856
Sales, general and administrative	9,239	4,755	16,676	7,622
Amortization	3	3	5	5
Depreciation	605	403	1,147	729
Total costs and expenses	17,909	12,287	33,244	21,212
Loss from operations	(17,889)	(12,268)	(33,061)	(21,179)
Interest expense and other	0	(2)	0	(3)
Foreign currency exchange loss	(117)	0	(73)	0
Interest and dividend income	140	18	194	33
Total other income	23	16	121	30
Net loss	$ (17,866)	$ (12,252)	$ (32,940)	$ (21,149)
Basic and diluted net loss per share (dollars per share)	$ (0.35)	$ (0.27)	$ (0.64)	$ (0.47)
Weighted average shares outstanding (shares)	51,213	44,678	51,205	44,664
Other comprehensive loss:
Net loss	$ (17,866)	$ (12,252)	$ (32,940)	$ (21,149)
Net unrealized gain (loss) on available-for-sale investments	29	(8)	81	(4)
Foreign currency translation adjustment	49	0	0	0
Comprehensive loss	$ (17,788)	$ (12,260)	$ (32,859)	$ (21,153)