Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenues:
Licensing and royalty revenues	$ 71	$ 122	$ 48
Product sales	76	0	0
Total revenues	147	122	48
Costs and expenses:
Research and development	26,022	19,526	10,673
Sales, general and administrative	17,882	10,695	4,312
Amortization	10	71	77
Depreciation	1,782	817	286
Impairment of intangibles	0	3	11
Total costs and expenses	45,696	31,112	15,359
Loss from operations	(45,549)	(30,990)	(15,311)
Interest expense and other	(23)	(7)	0
Interest and dividend income	74	64	29
Total other income	51	57	29
Net loss before income taxes	(45,498)	(30,933)	(15,282)
Net loss	$ (45,498)	$ (30,933)	$ (15,282)
Basic and diluted net loss per share (dollars per share)	$ (1.01)	$ (0.71)	$ (0.41)
Weighted average shares outstanding (shares)	44,998	43,626	37,599
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest	$ (45,498)	$ (30,933)	$ (15,282)
Other comprehensive loss:
Net loss	(45,498)	(30,933)	(15,282)
Net unrealized (loss) gain on available-for-sale investments	(20)	(15)	22
Foreign currency translation adjustment	1	0	0
Comprehensive loss	$ (45,517)	$ (30,948)	$ (15,260)